Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8260
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Type: Journal article
Title: Phase response relationships between light pulses and the melatonin rhythm in rats
Author: Stepien, J.
Kennaway, D.
Citation: Journal of Biological Rhythms, 2001; 16(3):234-242
Publisher: Sage Publications Inc
Issue Date: 2001
ISSN: 0748-7304
1552-4531
Statement of
Responsibility: 
Jacqueline M. Stepien and David J. Kennaway
Abstract: There is some controversy whether phase response curves constructed from studies conducted after acute release into constant darkness (Type II) or after prolonged constant darkness are comparable. This study investigated the effects of brief low-intensity light pulses on the onset of 6-sulphatoxymelatonin excretion in rats 48 to 60 h after lights-off and after 14 days of continuous darkness. In the former condition, maximum phase delays occurred between 4 and 6 h after expected lights-off, but no phase advances were observed within 2 days of the presentation of the stimulus. When the times of the pulses were plotted in relation to the individual onsets, peak light-induced phase delays occurred 0 to 2 h after melatonin onset. After 14 days in continuous darkness, the peak phase delays also occurred 0 to 2 h after melatonin onset and were slightly but significantly smaller. No significant phase advances were observed. In a separate small series of experiments, the temperature rhythm of rats was shown to be delayed by a comparable degree to that of melatonin by light pulses 2 and 4 h after expected lights-off under the Type II conditions. It is concluded that phase response curves conducted under Type I and Type II conditions are comparable.
Keywords: circadian
6-sulphatoxymelatonin
suprachiasmatic
Description: Copyright © 2001 by SAGE Publications
DOI: 10.1177/074873001129001944
Appears in Collections:Aurora harvest 4
Obstetrics and Gynaecology publications

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