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|Title:||Fos-icking for control of angiogenesis: Increasing the longevity of peritoneal dialysis|
|Citation:||Kidney International, 2013; 84(6):1065-1067|
|Publisher:||Blackwell Publishing Inc|
|Claudine S. Bonder and Lisa M. Ebert|
|Abstract:||Recurring peritonitis reduces the effectiveness of peritoneal dialysis by increasing fibrosis and angiogenesis, ultimately causing ultrafiltration failure (UFF). Identifying the processes underlying UFF will provide new hope for patients with chronic kidney disease. Catar and colleagues demonstrate that transforming growth factor-β, tumor necrosis factor-α, and interleukin-1 synergize to significantly increase the production and release of vascular endothelial growth factor by mesothelial cells, which, if untreated, will promote peritoneal angiogenesis, leading to UFF.|
|Keywords:||Peritoneum; Epithelial Cells; Humans; Peritonitis; Vascular Endothelial Growth Factor A; Proto-Oncogene Proteins c-fos; Transcription, Genetic|
|Rights:||© 2013 International Society of Nephrology|
|Appears in Collections:||Medicine publications|
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