Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/82657
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Type: Journal article
Title: Fos-icking for control of angiogenesis: Increasing the longevity of peritoneal dialysis
Author: Bonder, C.
Ebert, L.
Citation: Kidney International, 2013; 84(6):1065-1067
Publisher: Blackwell Publishing Inc
Issue Date: 2013
ISSN: 0085-2538
1523-1755
Statement of
Responsibility: 
Claudine S. Bonder and Lisa M. Ebert
Abstract: Recurring peritonitis reduces the effectiveness of peritoneal dialysis by increasing fibrosis and angiogenesis, ultimately causing ultrafiltration failure (UFF). Identifying the processes underlying UFF will provide new hope for patients with chronic kidney disease. Catar and colleagues demonstrate that transforming growth factor-β, tumor necrosis factor-α, and interleukin-1 synergize to significantly increase the production and release of vascular endothelial growth factor by mesothelial cells, which, if untreated, will promote peritoneal angiogenesis, leading to UFF.
Keywords: Peritoneum; Epithelial Cells; Humans; Peritonitis; Vascular Endothelial Growth Factor A; Proto-Oncogene Proteins c-fos; Transcription, Genetic
Rights: © 2013 International Society of Nephrology
RMID: 0020133493
DOI: 10.1038/ki.2013.306
Appears in Collections:Medicine publications

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