Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/82665
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Type: Journal article
Title: Is dietary zinc protective for type 2 diabetes? Results from the Australian longitudinal study on women's health
Author: Phungamla Vashum, K.
McEvoy, M.
Shi, Z.
Milton, A.
Islam, M.
Sibbritt, D.
Patterson, A.
Byles, J.
Loxton, D.
Attia, J.
Citation: BMC Endocrine Disorders, 2013; 13(1):1-8
Publisher: BioMed Central Ltd
Issue Date: 2013
ISSN: 1472-6823
1472-6823
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Responsibility: 
Khanrin Phungamla Vashum, Mark McEvoy, Zumin Shi, Abul Hasnat Milton, Md Rafiqul Islam, David Sibbritt, Amanda Patterson, Julie Byles, Deborah Loxton and John Attia
Abstract: BACKGROUND Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if dietary zinc is associated with risk of type 2 diabetes in a longitudinal study of mid-age Australian women. METHODS Data were collected from a cohort of women aged 45-50 years at baseline, participating in the Australian Longitudinal Study on Women’s Health. A validated food frequency questionnaire was used to assess dietary intake and other nutrients. Predictors of 6-year incidence of type 2 diabetes were examined using multivariable logistic regression. RESULTS From 8921 participants, 333 incident cases of type 2 diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile dietary zinc intake had almost half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I. 0.32–0.77) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing type 2 diabetes (OR = 0.50, 95% C.I 0.30-0.83) after multivariable adjustment of covariates. CONCLUSIONS Higher total dietary zinc intake and high zinc/iron ratio are associated with lower risk of type 2 diabetes in women. This finding is a positive step towards further research to determine if zinc supplementation may reduce the risk of developing type 2 diabetes.
Keywords: Diabetes
Australia
Women & Zinc
Rights: © 2013 Vashum et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1186/1472-6823-13-40
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