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dc.contributor.authorMoran, L.-
dc.contributor.authorNoakes, M.-
dc.contributor.authorClifton, P.-
dc.contributor.authorWittert, G.-
dc.contributor.authorTomlinson, L.-
dc.contributor.authorGalletly, C.-
dc.contributor.authorLuscombe-Marsh, N.-
dc.contributor.authorNorman, R.-
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2004; 89(7):3337-3344-
dc.descriptionCopyright © 2004 by The Endocrine Society-
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age associated with obesity. It may involve dysregulation of ghrelin, a hormone implicated in appetite regulation. The effect of diet composition on ghrelin is unclear. Overweight women with and without PCOS were randomized to a high-protein (40% carbohydrate, 30% protein; 10 PCOS, six non-PCOS) or standard protein diet (55% carbohydrate, 15% protein; 10 PCOS, six non-PCOS) for 12 wk of energy restriction and 4 wk of weight maintenance. Diet composition had no effect on fasting or postprandial ghrelin or measures of satiety. Non-PCOS subjects had a 70% higher fasting baseline ghrelin (P = 0.011), greater increase in fasting ghrelin (57.5 vs. 34.0%, P = 0.033), and greater maximal decrease in postprandial ghrelin after weight loss (–144.1 ± 58.4 vs. –28.9 ± 14.2 pg/ml, P = 0.02) than subjects with PCOS. Subjects with PCOS were less satiated (P = 0.001) and more hungry (P = 0.007) after a test meal at wk 0 and 16 than subjects without PCOS. Appetite regulation, as measured by subjective short-term hunger and satiety and ghrelin homeostasis, may be impaired in PCOS.-
dc.description.statementofresponsibilityL. J. Moran, M. Noakes, P. M. Clifton, G. A. Wittert, L. Tomlinson, C. Galletly, N. D. Luscombe and R. J. Norman-
dc.publisherEndocrine Society-
dc.subjectPolycystic Ovary Syndrome-
dc.subjectBody Weight-
dc.subjectPeptide Hormones-
dc.subjectBlood Glucose-
dc.subjectDietary Proteins-
dc.subjectPain Measurement-
dc.subjectCaloric Restriction-
dc.subjectRegression Analysis-
dc.subjectPatient Compliance-
dc.subjectSatiety Response-
dc.subjectBody Composition-
dc.subjectPostprandial Period-
dc.subjectMiddle Aged-
dc.titleGhrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition-
dc.typeJournal article-
dc.identifier.orcidMoran, L. [0000-0001-5772-6484]-
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]-
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]-
dc.identifier.orcidGalletly, C. [0000-0001-6185-9677]-
dc.identifier.orcidLuscombe-Marsh, N. [0000-0001-9690-4722]-
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]-
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