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Type: Journal article
Title: Pathological pain and the neuroimmune interface
Author: Grace, P.
Hutchinson, M.
Maier, S.
Watkins, L.
Citation: Nature Reviews Immunology, 2014; 14(4):217-231
Publisher: Nature Publishing Group
Issue Date: 2014
ISSN: 1474-1741
Organisation: Institute for Photonics & Advanced Sensing (IPAS)
Statement of
Peter M. Grace, Mark R. Hutchinson, Steven F. Maier & Linda R. Watkins
Abstract: Reciprocal signalling between immunocompetent cells in the central nervous system (CNS) has emerged as a key phenomenon underpinning pathological and chronic pain mechanisms. Neuronal excitability can be powerfully enhanced both by classical neurotransmitters derived from neurons, and by immune mediators released from CNS-resident microglia and astrocytes, and from infiltrating cells such as T cells. In this Review, we discuss the current understanding of the contribution of central immune mechanisms to pathological pain, and how the heterogeneous immune functions of different cells in the CNS could be harnessed to develop new therapeutics for pain control. Given the prevalence of chronic pain and the incomplete efficacy of current drugs — which focus on suppressing aberrant neuronal activity — new strategies to manipulate neuroimmune pain transmission hold considerable promise.
Keywords: Central Nervous System; Animals; Humans; Pain; Inflammation; Chemokines; Signal Transduction; Neuroimmunomodulation; Models, Biological; Toll-Like Receptors; Pain Management
Rights: © 2014 Macmillan Publishers Limited. All rights reserved.
RMID: 0030000080
DOI: 10.1038/nri3621
Appears in Collections:IPAS publications

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