Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/82978
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Type: Journal article
Title: Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder
Author: Fisher, H.
Cohen-Woods, S.
Hosang, G.
Korszun, A.
Owen, M.
Craddock, N.
Craig, I.
Farmer, A.
McGuffin, P.
Uher, R.
Citation: Journal of Affective Disorders, 2013; 145(1):136-141
Publisher: Elsevier Science BV
Issue Date: 2013
ISSN: 0165-0327
1573-2517
Statement of
Responsibility: 
Helen L. Fisher, Sarah Cohen-Woods, Georgina M. Hosang, Ania Korszun, Mike Owen, Nick Craddock, Ian W. Craig, Anne E. Farmer, Peter Mc Guffin, Rudolf Uher
Abstract: There is inconsistent evidence of interaction between stressful events and a serotonin transporter promoter polymorphism (5-HTTLPR) in depression. Recent studies have indicated that the moderating effect of 5-HTTLPR may be strongest when adverse experiences have occurred in childhood and the depressive symptoms persist over time. However, it is unknown whether this gene-environment interaction is present for recurrent depressive disorder and different forms of maltreatment. Therefore, patients with recurrent clinically diagnosed depression and controls screened for the absence of depression were utilised to examine the moderating effect of 5-HTTLPR on associations between specific forms of childhood adversity and recurrent depression.A sample of 227 recurrent unipolar depression cases and 228 never psychiatrically ill controls completed the Childhood Trauma Questionnaire to assess exposure to sexual, physical and emotional abuse, physical and emotional neglect in childhood. DNA extracted from blood or cheek swabs was genotyped for the short (s) and long (l) alleles of 5-HTTLPR.All forms of childhood maltreatment were reported as more severe by cases than controls. There was no direct association between 5-HTTLPR and depression. Significant interactions with additive and recessive 5-HTTLPR genetic models were found for overall severity of maltreatment, sexual abuse and to a lesser degree for physical neglect, but not other maltreatment types.The cross-sectional design limits causal inference. Retrospective report of childhood adversity may have reduced the accuracy of the findings.This study provides support for the role of interplay between 5-HTTLPR and a specific early environmental risk in recurrent depressive disorder.
Keywords: Childhood maltreatment; Unipolar depression; Recurrent; Serotonin transporter gene; Gene–environment interaction; 5-HTTLPR
Rights: © 2012 Elsevier B.V. All rights reserved
RMID: 0020124305
DOI: 10.1016/j.jad.2012.05.032
Published version: http://www.sciencedirect.com/science/article/pii/S0165032712003862
Appears in Collections:Psychiatry publications

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