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Type: Journal article
Title: Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia
Author: Holmes, N.
Turnidge, J.
Munckhof, W.
Robinson, J.
Korman, T.
O'Sullivan, M.
Anderson, T.
Roberts, S.
Warren, S.
Gao, W.
Johnson, P.
Howden, B.
Citation: Clinical Microbiology and Infection, 2013; 19(12):1163-1168
Publisher: Blackwell Science Ltd
Issue Date: 2013
ISSN: 1198-743X
Statement of
N. E. Holmes, J. D. Turnidge, W. J. Munckhof, J. O. Robinson, T. M. Korman, M. V. N. O’Sullivan, T. L. Anderson, S. A. Roberts, S. J. C. Warren, W. Gao, P. D. R. Johnson, and B. P. Howden
Abstract: We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.
Keywords: Bacteraemia
Staphylococcus aureus
vancomycin minimum inhibitory concentration
Rights: © 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases
DOI: 10.1111/1469-0691.12168
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Appears in Collections:Aurora harvest
Paediatrics publications

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