Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8344
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dc.contributor.authorMacLennan, A.en
dc.contributor.authorGrant, P.en
dc.contributor.authorBryant-Greenwood, G.en
dc.date.issued1995en
dc.identifier.citationJournal of Reproductive Medicine, 1995; 40(10):703-706en
dc.identifier.issn0024-7758en
dc.identifier.issn1943-3565en
dc.identifier.urihttp://hdl.handle.net/2440/8344-
dc.description.abstract<h4>Objective</h4>To study the effect of synthetic h RLX-1 peptide on human and porcine myometrium in vitro in comparison to the effect of h RLX-2 peptide.<h4>Study design</h4>Myometrial strips from humans and pigs in late pregnancy were allowed to spontaneously contract in an organ bath. Muscle activity was recorded isometrically in response to varying doses of h RLX-1.<h4>Results</h4>Synthetic h RLX-1 peptide at 0.13 micrograms/mL caused sustained and complete inhibition of pregnant pig myometrial contractility, comparable to that produced by the h RLX-2 peptide, showing, for the first time, its biologic activity in this system. However, a range of concentrations of h RLX-1 peptide (0.07-7.32 micrograms/mL) had no effect on human myometrial contractions in vitro, whereas h RLX-2 peptide had some, albeit minimal, activity in this system.<h4>Conclusion</h4>This result shows that h RLX-1 peptide does not appear to be an inhibitor of human myometrial activity and that although the pig myometrial relaxin receptor does not appear to distinguish between the two human relaxins, the human relaxin receptor might. Thus, the control of spontaneous myometrial activity during pregnancy in the human appears to be different from that in other species.en
dc.language.isoenen
dc.publisherJournal of Reproductive Medicine Inc.en
dc.subjectMyometrium; Animals; Swine; Humans; Relaxin; Recombinant Proteins; Drug Evaluation, Preclinical; Pregnancy; Uterine Contraction; Dose-Response Relationship, Drug; Female; In Vitro Techniquesen
dc.titlehRLX-1 in vitro response of human and pig myometriumen
dc.typeJournal articleen
dc.identifier.rmid0030005225en
dc.identifier.pubid69231-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Obstetrics and Gynaecology publications

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