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Type: Journal article
Title: Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm
Author: Smallwood, L.
Allcock, R.
van Bockxmeer, F.
Warrington, N.
Palmer, L.
Iacopetta, B.
Golledge, J.
Norman, P.
Citation: British Journal of Surgery, 2008; 95(10):1239-1244
Publisher: John Wiley & Sons Ltd
Issue Date: 2008
ISSN: 0007-1323
Statement of
L. Smallwood, R. Allcock, F. van Bockxmeer, N. Warrington, L. J. Palmer, B. Iacopetta, J. Golledge and P. E. Norman
Abstract: <h4>Background</h4>Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA.<h4>Methods</h4>The -1562C > T and -1811A > T variants of the MMP-9 gene were genotyped in 678 men with an AAA (at least 30 mm in diameter) and 659 control subjects (aortic diameter 19-22 mm) recruited from a population-based trial of screening for AAA. Levels of MMP-9 were measured in a random subset of 300 cases and 84 controls. The association between genetic variants (including haplotypes) and AAA was assessed by multivariable logistic regression.<h4>Results</h4>There was no association between the MMP-9-1562C > T (odds ratio (OR) 0.70 (95 per cent confidence interval (c.i.) 0.27 to 1.82)) or -1811A > T (OR 0.71 (95 per cent c.i. 0.28 to 1.85)) genotypes, or the most common haplotype (OR 0.81 (95 per cent c.i. 0.62 to 1.05)) and AAA. The serum MMP-9 concentration was higher in cases than controls, and in minor allele carriers in cases and controls, although the differences were not statistically significant.<h4>Conclusion</h4>In this study, the genetic tendency to higher levels of circulating MMP-9 was not associated with AAA.
Keywords: Humans; Aortic Aneurysm, Abdominal; Case-Control Studies; Genotype; Polymorphism, Genetic; Aged; Aged, 80 and over; Male; Matrix Metalloproteinase 9
Rights: Copyright © 2008 British Journal of Surgery Society Ltd.
RMID: 0020136658
DOI: 10.1002/bjs.6345
Appears in Collections:Medicine publications

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