Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Molecular and Cellular Endocrinology, 2002; 191(1):57-64||en|
|dc.description.abstract||Much is known about the control of the development of ovarian follicles by growth factors and hormones. The study of extracellular matrix in the ovary, though, is a relatively new area. To date much research has focused on identifying the matrix components present, and more recently, its production and the physiological roles. In this review we focus on the changes that occur in the follicular basal lamina from primordial follicles through to ovulation and formation of the corpus luteum, the changes that occur during follicular atresia, and we discuss our observations of a novel matrix which forms in the membrana granulosa. The follicular basal lamina changes considerably during follicular development in its expression pattern of type IV collagens. Of the laminin chains examined, there appears only to be an increase in amount, except for laminin α2. It is expressed only in a small proportion of healthy antral follicles and in the majority of atretic antral follicles. Call–Exner bodies have the same composition as the basal lamina, except they do not contain laminin α2, even when the follicular basal lamina does. The novel matrix that develops within the membrana granulosa is similar in composition to Call–Exner bodies which occur predominantly in preantral follicles, except that it is far more common in large antral follicles, does not induce polarization of the surrounding granulosa cells, and does not contain follicular fluid-like material as the Call–Exner bodies of some species do. The expression of this matrix occurs prior to and during the time when granulosa cells express steroidogenic enzymes. It does not exist in corpora lutea. In addition large luteal cells, derived from granulosa cells, do not appear to have a basal lamina. These findings suggest that the maturational changes in the membrana granulosa are accompanied by changes in the matrix.||en|
|dc.description.statementofresponsibility||R. J. Rodgers, and H. F. Irving Rodgers||en|
|dc.publisher||Elsevier Sci Ireland Ltd||en|
|dc.subject||Basal lamina; Ovarian follicle; Ultrastructure||en|
|dc.title||Extracellular matrix of the bovine ovarian membrana granulosa||en|
|pubs.library.collection||Obstetrics and Gynaecology publications||en|
|dc.identifier.orcid||Rodgers, R. [0000-0002-2139-2969]||en|
|Appears in Collections:||Obstetrics and Gynaecology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.