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Type: Journal article
Title: Polymorphisms in the tumor necrosis factor and lymphotoxin-a gene region and preeclampsia
Author: Lachmeijer, A.
Crusius, J.
Pals, G.
Dekker, G.
Arngrimsson, R.
ten Kate, L.
Citation: Obstetrics and Gynecology, 2001; 98(4):612-619
Publisher: Elsevier Science Inc
Issue Date: 2001
ISSN: 0029-7844
Abstract: OBJECTIVE: To investigate potential association or linkage among nine polymorphisms in the genes encoding tumor necrosis factor (TNF) or lymphotoxin (LT) and preeclampsia. METHODS: Four di-allelic polymorphisms and five microsatellite markers in the genes encoding TNF- (TNF) and LT (LTA) and their haplotypes were studied in 150 Dutch families. These families contained sib-pairs of women affected with preeclampsia; eclampsia; the hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome (strict criteria); or pregnancy-induced hypertension (mild criteria). Frequencies were compared with 98 healthy controls. Nonparametric affected sib-pair analyses for allele sharing among siblings were carried out for all nine markers. Each sibship was composed of an affected index woman and one or more affected sisters. RESULTS: Although we found a striking association with the TNF-I haplotype in 30 index women with (pre-)eclampsia or HELLP syndrome compared with controls (odds ratio [OR] 3.8; 95% confidence interval [CI] 1.6, 8.9), this association was not found in their 30 sisters meeting similar disease criteria. Analyses in all 150 families showed a similar TNF-I association in 122 index women meeting the strict criteria compared with controls (OR 1.9; 95% CI 1.1, 3.3), but, again, not in their 91 sisters meeting similar disease criteria. This association was stronger in a subgroup of 75 index women with preeclampsia only (OR 2.3; 95% CI 1.2, 4.2). No excess allele sharing for any marker was seen between the siblings. CONCLUSION: The nine polymorphisms studied in the TNF-LTA region did not show evidence for association or linkage with familial preeclampsia.
Keywords: Humans
HELLP Syndrome
Tumor Necrosis Factor-alpha
Case-Control Studies
Pilot Projects
Microsatellite Repeats
Lod Score
Polymorphism, Genetic
Description: © 2001 by The American College of Obstetricians and Gynecologists
DOI: 10.1016/S0029-7844(01)01487-9
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Obstetrics and Gynaecology publications

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