Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Polymorphisms in the tumor necrosis factor and lymphotoxin-a gene region and preeclampsia|
ten Kate, L.
|Citation:||Obstetrics and Gynecology, 2001; 98(4):612-619|
|Publisher:||Elsevier Science Inc|
|Abstract:||OBJECTIVE: To investigate potential association or linkage among nine polymorphisms in the genes encoding tumor necrosis factor (TNF) or lymphotoxin (LT) and preeclampsia. METHODS: Four di-allelic polymorphisms and five microsatellite markers in the genes encoding TNF- (TNF) and LT (LTA) and their haplotypes were studied in 150 Dutch families. These families contained sib-pairs of women affected with preeclampsia; eclampsia; the hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome (strict criteria); or pregnancy-induced hypertension (mild criteria). Frequencies were compared with 98 healthy controls. Nonparametric affected sib-pair analyses for allele sharing among siblings were carried out for all nine markers. Each sibship was composed of an affected index woman and one or more affected sisters. RESULTS: Although we found a striking association with the TNF-I haplotype in 30 index women with (pre-)eclampsia or HELLP syndrome compared with controls (odds ratio [OR] 3.8; 95% confidence interval [CI] 1.6, 8.9), this association was not found in their 30 sisters meeting similar disease criteria. Analyses in all 150 families showed a similar TNF-I association in 122 index women meeting the strict criteria compared with controls (OR 1.9; 95% CI 1.1, 3.3), but, again, not in their 91 sisters meeting similar disease criteria. This association was stronger in a subgroup of 75 index women with preeclampsia only (OR 2.3; 95% CI 1.2, 4.2). No excess allele sharing for any marker was seen between the siblings. CONCLUSION: The nine polymorphisms studied in the TNF-LTA region did not show evidence for association or linkage with familial preeclampsia.|
|Keywords:||Humans; Eclampsia; HELLP Syndrome; Pre-Eclampsia; Tumor Necrosis Factor-alpha; Case-Control Studies; Pilot Projects; Microsatellite Repeats; Pregnancy; Haplotypes; Lod Score; Polymorphism, Genetic; Female; Lymphotoxin-alpha|
|Description:||© 2001 by The American College of Obstetricians and Gynecologists|
|Appears in Collections:||Obstetrics and Gynaecology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.