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Type: Conference paper
Title: The loading and release property of nanoporous anodic alumina for delivery of drugs and drug carriers
Author: Aw, M.
Simovic, S.
Dhiraj, K.
Addai-Mensah, J.
Losic, D.
Citation: ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology / pp.143-145
Publisher: IEEE
Publisher Place: Australia
Issue Date: 2010
ISBN: 9781424452620
Conference Name: International Conference on Nanoscience and Nanotechnology (2010 : Sydney, Australia)
Statement of
Moom Sinn Aw, Spomenka Simovic, Kumar Dhiraj, Jonas Addai-Mensah and Dusan Losic
Abstract: A two-step electrochemical anodisation approach was adopted in this work to create a series of highly ordered mesopores etched with different diameter (60 to 160 nm) and uniform nanotube length in anodised aluminium oxide (AAO). The loading and release characteristics of model drug (indomethacin) and drug carriers (micelles named Pluronic F127, TPGS, PEO-PPO-PEO) were presented to investigate the influence of micelle size, pore diameter and surface modification of AAO on release studies. Surface chemistry was varied via silanation process, using AFTES and PFPTES. It was discovered that quicker release of drugs was induced by larger pore size and smaller micelles. Moreover drug release was found to favour hydrophobic surface as the release was faster in PFPTES modified AAO than the one with APTES.
Keywords: anodic alumina; polymeric micelle; drug delivery; drug carrier
Rights: Copyright © 2010 IEEE
RMID: 0020128417
DOI: 10.1109/ICONN.2010.6045213
Appears in Collections:Chemical Engineering publications

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