Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8437
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dc.contributor.authorPhillips, I.-
dc.contributor.authorSimonetta, G.-
dc.contributor.authorOwens, J.-
dc.contributor.authorRobinson, J.-
dc.contributor.authorClarke, I.-
dc.contributor.authorMcMillen, I.-
dc.date.issued1996-
dc.identifier.citationPediatric Research, 1996; 40(6):861-866-
dc.identifier.issn0031-3998-
dc.identifier.issn1530-0447-
dc.identifier.urihttp://hdl.handle.net/2440/8437-
dc.description.abstractWe have experimentally restricted placental growth in the sheep to investigate the impact of reduced substrate delivery on fetal pituitary proopiomelanocortin (POMC) mRNA levels and on circulating ACTH 1-39, immunoreactive ACTH, and cortisol concentrations during late gestation. Endometrial caruncles were removed in nine ewes before mating to reduce the number of placentomes formed [placental restriction group (PR)]. Fetal arterial Po2 and O2 saturation were reduced in the PR group (2.0± 0.1 kPa and 42.8 ± 1.1%, n = 9) when compared with control fetuses (3.1 ± 0.1 kPa and 66.4 ± 0.9%, n = 10). The ratio of anterior pituitary POMC mRNA:18 S ribosomal RNA was also lower (p < 0.05) in the PR group (0.49 ± 0.05) when compared with the control group (0.80 ± 0.12) after 140 d of gestation. In contrast, plasma concentrations of ACTH 1-39 and immunoreactive ACTH were similar in the PR and control groups throughout late gestation. Plasma ACTH 1-39 concentrations increased (p < 0.006) between 128 and 134 d of gestation, in both the PR (122-128 d: 2.70 ± 0.34 pmol/L: 134-141 d; 7.07 ± 1.57 pmol/L) and control (122-128 d; 3.36 ± 0.56 pmol/L: 134-141 d; 10.78 ± 2.88 pmol/L) groups. Combined adrenal weight was higher (p < 0.005) in the PR group (130 ± 10 mg/kg) compared with controls (80 ± 1 mg/kg) at 140 d of gestation, and plasma cortisol concentrations were also higher (p < 0.02) in PR than control fetuses between 127 and 141 d of gestation. These changes imply that the fetal hypothalamopituitary-adrenal axis is operating at a new central set point in the growth-restricted fetus.-
dc.description.statementofresponsibilityIan D Phillips, Giuseppe Simonetta, Julie A Owens, Jeffrey S Robinson, Iain J Clarke and I Caroline McMillen-
dc.language.isoen-
dc.publisherWILLIAMS & WILKINS-
dc.source.urihttp://dx.doi.org/10.1203/00006450-199612000-00014-
dc.subjectPituitary-Adrenal System-
dc.subjectPituitary Gland, Anterior-
dc.subjectFetal Blood-
dc.subjectPlacenta-
dc.subjectAnimals-
dc.subjectSheep-
dc.subjectOxygen-
dc.subjectHydrocortisone-
dc.subjectPro-Opiomelanocortin-
dc.subjectRNA, Messenger-
dc.subjectRegression Analysis-
dc.subjectEmbryonic and Fetal Development-
dc.subjectGestational Age-
dc.subjectPregnancy-
dc.subjectPartial Pressure-
dc.subjectFemale-
dc.subjectAdrenocorticotropic Hormone-
dc.titlePlacental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation-
dc.typeJournal article-
dc.identifier.doi10.1203/00006450-199612000-00014-
pubs.publication-statusPublished-
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]-
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]-
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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