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Type: Conference paper
Title: Porous silica microparticles from diatomaceous earth (DE) for drug delivery applications
Author: Aw, M.
Simovic, S.
Yu, Y.
Addai-Mensah, J.
Losic, D.
Citation: Chemeca 2010: Engineering at the Edge, 26-29 September 2010, Hilton Adelaide, South Australia: pp.[1107]-[1116]
Publisher: Engineers Australia
Publisher Place: Barton, ACT; Australia
Issue Date: 2010
ISBN: 9780858259713
Conference Name: CHEMECA (38th : 2010 : Adelaide, Australia)
Statement of
Moom Sinn Aw, Spomenka Simovic, Yang Yu, Jonas Addai-Mensah, Dusan Losic
Abstract: Numerous mesoporous materials have been investigated in the last two decades to address therapeutic problems in drug delivery; for instance, poor bioavailability, low biodistribution, limited drug solubility, lack of selectivity and undesirable pharmacokinetics. In this work, a novel concept of using a silica-based natural mineral, referred to as diatomaceous earth (DE), as a drug carrier is explored. DE is formed from algae, a type of unicellular phytoplankton, through its silica shells (frustules) growth with ordered porous structures. To prove this concept we investigate loading and release of indomethacin, a poorly soluble drug from DE microparticles. The carrying capacity of DE was 22 wt % whereas indomethacin molecules in DE pores was released over a period of 12 days. This work demonstrates the application of DE microparticles as a drug carrier for sustainable release of drugs.
Description: CHEMECA 2010
Rights: © 2010 Engineers Australia
RMID: 0020138934
Published version:;dn=976126446451683;res=IELENG
Appears in Collections:Chemical Engineering publications

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