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Type: Journal article
Title: Purification and structural analyses of ABCG2
Author: McDevitt, C.
Collins, R.
Kerr, I.
Callaghan, R.
Citation: Advanced Drug Delivery Reviews, 2009; 61(1):57-65
Publisher: Elsevier Science
Issue Date: 2009
ISSN: 0169-409X
Statement of
Christopher A. McDevitt, Richard Collins, Ian D. Kerr, Richard Callaghan
Abstract: ABCG2 is best known as a multidrug transporter capable of conferring resistance to cancer cells. However, the protein is also inherently expressed in numerous barrier tissues and intriguingly within hematopoietic stem cells. Unlike its partners ABCB1 and ABCC1, there is considerably less information available on the molecular mechanism of ABCG2. The transporter has a distinct topology and is presumed to function as a homodimer. However, a number of biochemical studies have presented data to suggest that the protein adopts higher order oligomers. This review focuses on this controversial issue with particular reference to findings from low resolution structural data. In addition, a number of molecular models of ABCG2 based on high resolution structures of bacterial ABC transporters have recently become available and are critically assessed. ABCG2 is a structurally distinct member of the triumvirate of human multidrug transporters and continues to evade description of a unifying molecular mechanism.
Keywords: Multidrug resistance; multidrug efflux; membrane protein solubilisation; electron microscopy; oligomerisation; molecular modelling; structural analysis
Rights: © 2008 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.addr.2008.07.004
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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