Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/84500
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Type: Journal article
Title: Hypoxia-inducible factor-1α gene polymorphisms in early and late onset preeclampsia in Sinhalese women
Other Titles: Hypoxia-inducible factor-1alpha gene polymorphisms in early and late onset preeclampsia in Sinhalese women
Author: Andraweera, P.
Dekker, G.
Thompson, S.
Dissanayake, V.
Jayasekara, R.
Roberts, C.
Citation: Placenta, 2014; 35(7):491-495
Publisher: Elsevier
Issue Date: 2014
ISSN: 1532-3102
1532-3102
Statement of
Responsibility: 
P.H. Andraweera, G.A. Dekker, S.D. Thompson, V.H.W. Dissanayake, R.W. Jayasekara, C.T. Roberts
Abstract: INTRODUCTION: Early (EPE) and late (LPE) onset preeclampsia are increasingly being recognized as two distinct disorders. Placental vascular defects are more common in EPE. Hypoxia Inducible Factor 1α (HIF1α) regulates the expression of many angiogenic growth factors in the placenta. We studied the association of two polymorphisms in the HIF1α gene (rs11549465 and rs10873142) with EPE and LPE. METHODS: 175 nulliparous Sinhalese women with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited at two tertiary care hospitals in Colombo. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral blood was genotyped using Sequenom MassARRAY. RESULTS: HIF1α rs11549465 dominant model and T allele were reduced in women who developed EPE compared to controls [P = 0.002, OR (95% CI) = 0.3 (0.1-0.7)], in preeclamptic women who delivered small for gestational age babies [P = 0.02, OR (95% CI) = 0.5 (0.2-0.9)] compared to controls and in women who developed EPE compared to those who developed LPE [P = 0.006, OR (95% CI) = 0.3 (0.1-0.7)]. CONCLUSION: Our results demonstrate a protective effect of the T allele in LPE and normal pregnancy, which is relatively lacking in EPE due to low prevalence of this protective allele. HIF1α rs11549465 T allele was previously demonstrated to be associated with a higher transcriptional activity and increased angiogenesis. Inherited susceptibility to increased HIF1α expression resulting in the up-regulation of angiogenic genes may mediate a protective effect in normal pregnancy and pregnancy complicated by LPE.
Keywords: Hypoxia inducible factor 1α; Polymorphism; Preeclampsia
Rights: © 2014 Elsevier Ltd.
RMID: 0020138762
DOI: 10.1016/j.placenta.2014.04.008
Grant ID: http://purl.org/au-research/grants/nhmrc/519225
http://purl.org/au-research/grants/nhmrc/1020749
Appears in Collections:Paediatrics publications

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