Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: CD83+ dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy
Author: Askelund, K.
Liddell, H.
Zanderigo, A.
Fernando, N.
Khong, T.
Stone, P.
Chamley, L.
Citation: Placenta, 2004; 25(2-3):140-145
Publisher: W B Saunders Co Ltd
Issue Date: 2004
ISSN: 0143-4004
Abstract: Immunological factors have been postulated to play a role in the aetiology of recurrent miscarriage as the fetus and placenta are semi-allogenic to the mother. Potent immunostimulatory (CD83(+)) dendritic cells have recently been identified in the uterine decidua. This study was conducted to examine whether decidual dendritic cells could play a role in the aetiology of recurrent miscarriage. First trimester placental and decidual biopsies were obtained from 40 women with recurrent miscarriage and 15 gestation-matched normal controls. These biopsies were screened by immunohistochemistry for CD83(+)cells. Staining was analysed by light microscopy and digital image analysis. In both recurrent miscarriage and normal pregnancy, CD83(+)dendritic cells were localized to the decidua. Individual dendritic cells were present in the decidual stroma or in clusters of 3-4 dendritic cells, in lymphoid aggregates. There were no significant differences in decidual CD83(+)dendritic cell density between women with recurrent miscarriage and normal pregnancy when the groups were compared as a whole. However, when segregated by gestational age, decidua from women with recurrent miscarriage at 8 weeks' gestation contained significantly more dendritic cells than gestational age-matched normal controls. This suggests dendritic cells may play a role in the aetiology of some cases of recurrent miscarriage.
Keywords: Decidua
Dendritic Cells
Abortion, Habitual
Membrane Glycoproteins
Antigens, CD
Fluorescent Antibody Technique, Indirect
Pregnancy Trimester, First
DOI: 10.1016/S0143-4004(03)00182-6
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.