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|Title:||CD83+ dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy|
|Citation:||Placenta, 2004; 25(2-3):140-145|
|Publisher:||W B Saunders Co Ltd|
|Abstract:||Immunological factors have been postulated to play a role in the aetiology of recurrent miscarriage as the fetus and placenta are semi-allogenic to the mother. Potent immunostimulatory (CD83(+)) dendritic cells have recently been identified in the uterine decidua. This study was conducted to examine whether decidual dendritic cells could play a role in the aetiology of recurrent miscarriage. First trimester placental and decidual biopsies were obtained from 40 women with recurrent miscarriage and 15 gestation-matched normal controls. These biopsies were screened by immunohistochemistry for CD83(+)cells. Staining was analysed by light microscopy and digital image analysis. In both recurrent miscarriage and normal pregnancy, CD83(+)dendritic cells were localized to the decidua. Individual dendritic cells were present in the decidual stroma or in clusters of 3-4 dendritic cells, in lymphoid aggregates. There were no significant differences in decidual CD83(+)dendritic cell density between women with recurrent miscarriage and normal pregnancy when the groups were compared as a whole. However, when segregated by gestational age, decidua from women with recurrent miscarriage at 8 weeks' gestation contained significantly more dendritic cells than gestational age-matched normal controls. This suggests dendritic cells may play a role in the aetiology of some cases of recurrent miscarriage.|
|Keywords:||Decidua; Dendritic Cells; Humans; Abortion, Habitual; Immunoglobulins; Membrane Glycoproteins; Antigens, CD; Fluorescent Antibody Technique, Indirect; Pregnancy; Pregnancy Trimester, First; Adult; Female|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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