Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/84635
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Type: Journal article
Title: Estimating the risk of gestational diabetes mellitus: a clinical prediction model based on patient characteristics and medical history
Author: van Leeuwen, M.
Opmeer, B.
Zweers, E.
van Ballegooie, E.
ter Brugge, H.
de Valk, H.
Visser, G.
Mol, B.
Citation: BJOG, 2010; 117(1):69-75
Publisher: Blackwell
Issue Date: 2010
ISSN: 1470-0328
1471-0528
Statement of
Responsibility: 
M van Leeuwen, BC Opmeer, EJK Zweers, E van Ballegooie, HG ter Brugge, HW de Valk, GHA Visser, BWJ Mol
Abstract: Objective: To develop a clinical prediction rule that can help the clinician to identify women at high and low risk for gestational diabetes mellitus (GDM) early in pregnancy in order to improve the efficiency of GDM screening. Design: We used data from a prospective cohort study to develop the clinical prediction rule. Setting: The original cohort study was conducted in a university hospital in the Netherlands. Population: Nine hundred and ninety-five consecutive pregnant women underwent screening for GDM. Methods: Using multiple logistic regression analysis, we constructed a model to estimate the probability of development of GDM from the medical history and patient characteristics. Receiver operating characteristics analysis and calibration were used to assess the accuracy of the model. Main outcome measure: The development of a clinical prediction rule for GDM. We also evaluated the potential of the prediction rule to improve the efficiency of GDM screening. Results: The probability of the development of GDM could be predicted from the ethnicity, family history, history of GDM and body mass index. The model had an area under the receiver operating characteristic curve of 0.77 (95% CI 0.69–0.85) and calibration was good (Hosmer and Lemeshow test statistic, P = 0.25). If an oral glucose tolerance test was performed in all women with a predicted probability of 2% or more, 43% of all women would be tested and 75% of the women with GDM would be identified. Conclusions: The use of a clinical prediction model is an accurate method to identify women at increased risk for GDM, and could be used to select women for additional testing for GDM.
Keywords: Gestational diabetes mellitus; prediction model; screening
Rights: © 2009 The Authors
RMID: 0020136760
DOI: 10.1111/j.1471-0528.2009.02425.x
Appears in Collections:Obstetrics and Gynaecology publications

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