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|dc.identifier.citation||Journal of Maternal-Fetal & Neonatal Medicine, 2011; 24(10):1215-1220||en|
|dc.description.abstract||Objective: Dysregulated vascular resistance contributes to hypotension following preterm birth with sex-specific differences in microvascular function conferring a male disadvantage. We hypothesized that glucocorticoid mediated, sex-specific differences in the endogenous catecholamine norepinephrine and endothelially derived endothelin-1 (ET-1) contribute to microvascular dysfunction in preterm neonates in the immediate newborn period. Methods: Umbilical and plasma ET-1 and normetanephrine, in 24 h urine samples, were determined at 24, 72, and 120 h of age in 24–34 week infants (n = 60). Microvascular blood flow was determined by laser Doppler flowmetry. Results: In infants born within 72 h of antenatal glucocorticoid exposure, normetanephrine was higher in females than males (p = 0.048). Normetanephrine was inversely correlated with both microvascular blood flow at 24 h (p = 0.025) and CRIB II (p = 0.001). While umbilical arterial ET-1 was higher in females delivered <72 h after antenatal betamethasone (p = 0.006), plasma ET-1 did not correlate with microvascular blood flow or illness severity. Only sex and normetanephrine contributed significantly to both microvascular blood flow and endothelium dependant vasodilatation. Conclusions: These data support glucocorticoid mediated, sex-specific differences in mediators of vascular tone that may contribute to the impaired mechanisms compromising successful hemodynamic adaption to neonatal life and resulting in excess male morbidity and mortality.||en|
|dc.description.statementofresponsibility||Michael J. Stark, Nicolette A. Hodyl, Ian M. R. Wright & Vicki Clifton||en|
|dc.rights||© 2011 Informa UK, Ltd.||en|
|dc.subject||Neonate; glucocorticoids; endothelin-1; normetanephrine; vascular tone||en|
|dc.title||The influence of sex and antenatal betamethasone exposure on vasoconstrictors and the preterm microvasculature||en|
|dc.identifier.orcid||Stark, M. [0000-0003-1835-8679]||en|
|dc.identifier.orcid||Hodyl, N. [0000-0003-2025-5310]||en|
|dc.identifier.orcid||Clifton, V. [0000-0002-4892-6748]||en|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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