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Type: Journal article
Title: G protein-coupled receptor heteromer identification technology: identification and profiling of GPCR heteromers
Author: Mustafa, S.
Pfleger, K.
Citation: Journal of Laboratory Automation, 2011; 16(4):285-291
Publisher: Sage Publications
Issue Date: 2011
ISSN: 2211-0682
Statement of
Sanam Mustafa and Kevin D.G. Pfleger
Abstract: Traditionally, G protein-coupled receptors (GPCRs) were thought to function as monomeric units activating linear signaling pathways to reach a single functional response. However, it is now recognized that GPCRs can exist as higher order structures, such as homomers or heteromers. The potential for unique pharmacology attributed to these GPCR complexes has opened up the possibility of a new class of targets that can be exploited for drug discovery. In this innovation brief, a novel technology developed to identify and profile GPCR heteromers and their ligands will be reviewed.
Keywords: G protein-coupled; receptor; GPCR; heteromer; GPCR-HIT; BRET
Rights: Copyright © 2011 by the Society for Laboratory Automation and Screening
RMID: 0020138134
DOI: 10.1016/j.jala.2011.03.002
Appears in Collections:Physiology publications

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