Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/8489
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Type: Journal article
Title: Placental control of fetal growth
Author: Robinson, J.
Chidzanja, S.
Kind, K.
Owens, P.
Owens, J.
Citation: Reproduction, Fertility and Development, 1995; 7(3):333-344
Publisher: CSIRO
Issue Date: 1995
ISSN: 1031-3613
1448-5990
Abstract: The placenta exerts its effects on the growth of the fetus from the beginning of pregnancy via metabolic and endocrine mechanisms. To achieve this, the placenta exchanges a wide array of nutrients, endocrine signals, cytokines and growth factors with the mother and the fetus. These exchanges modulate or programme fetal growth and development. This review concentrates on the function and structure of the placenta in humans and in animals, and the effects of experimental perturbation of placental size and function on fetal growth. The consequences for fetal growth of varying the abundance of peptides or, by deleting genes, insulin-like growth factors or cytokines, are also described. Maternal nutritional and hormonal state from as early as the first few days after fertilization, can influence the growth rate of the placenta and the fetus and also the length of gestation. Influences on placental development and their consequences will clearly have an impact on the placental control of fetal growth. Variations in the maternal environment and consequent perturbation of the metabolic and endocrine environment of the placenta and fetus are implicated as being responsible for the associations between prenatal growth of the placenta and its fetus and the subsequent risk of adult disease. The next challenge will be to determine the dominant influences at each stage of fetal and placental growth.
Keywords: Placenta; Animals; Humans; Chromosome Aberrations; Growth Substances; Cytokines; Body Constitution; Embryonic and Fetal Development; Pregnancy; Female; Nutritional Physiological Phenomena
RMID: 0030005183
DOI: 10.1071/RD9950333
Appears in Collections:Obstetrics and Gynaecology publications

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