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Type: Journal article
Title: Placental vascular development and neonatal outcome
Author: Khong, T.
Citation: Seminars in Fetal & Neonatal Medicine, 2004; 9(4):255-263
Publisher: Elsevier Ltd.
Issue Date: 2004
ISSN: 1744-165X
Abstract: The juxtaposition of the maternal and fetal circulations allows optimal physiological exchange between mother and fetus. Extravillous trophoblast infiltrating into the placental bed transforms the small calibre spiral arteries into large calibre uteroplacental arteries. The absence of these physiological changes, coupled with other lesions such as acute atherosis, results in a reduced uteroplacental blood flow, as seen in pre-eclampsia, intrauterine growth restriction and preterm delivery. A failure to elaborate the placental vascular tree can result in impaired flow through the fetal placental circulation. Placental vascular malformations, such as placental mesenchymal dysplasia and the commoner chorangioma, can lead to neonatal complications. Fetal thrombotic vasculopathy, commonly associated with thrombophilia, may be a cause of neurological deficit in childhood.
Keywords: Placenta; Humans; Placenta Diseases; Pregnancy Outcome; Embryonic and Fetal Development; Pregnancy; Maternal-Fetal Exchange; Placentation; Neovascularization, Physiologic; Infant, Newborn; Female
RMID: 0020041248
DOI: 10.1016/j.siny.2003.11.010
Appears in Collections:Obstetrics and Gynaecology publications

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