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Type: Journal article
Title: The immunology of preeclampsia
Author: Dekker, G.
Sibai, B.
Citation: Seminars in Perinatology, 1999; 23(1):24-33
Publisher: Grune & Stratton
Issue Date: 1999
ISSN: 0146-0005
Statement of
Gustaaf A. Dekker and Baha M. Sibai
Abstract: The immune maladaptation hypothesis of preeclampsia is concordant with cytokine-mediated oxidative stress, chronology of endothelial activation, lipid changes, adverse effect of changing partners, and the protective effect of sperm exposure. Genetic factors may involve underlying hereditary thrombophilic disorders and hyperhomocysteinemia, essential hypertension and/or obesity, or control of the Th1/Th2 balance and thus affect the maternal response against fetal antigens. Placental ischemia and increased syncytiotrophoblast deportation are probably end-stage disease phenomena.
Keywords: Uterus; Fetus; Placenta; Humans; Pre-Eclampsia; Ischemia; Antigens; Pregnancy; Vasoconstriction; Female
RMID: 0030005177
DOI: 10.1016/S0146-0005(99)80057-3
Appears in Collections:Obstetrics and Gynaecology publications

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