Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85254
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Type: Journal article
Title: High live birth rate in the subsequent IVF cycle after first-cycle poor response among women with mean age 35 and normal FSH
Author: Moolenaar, L.
Mohiuddin, S.
Davie, M.
Merrilees, M.
Broekmans, F.
Mol, B.
Johnson, N.
Citation: Reproductive Biomedicine Online, 2013; 27(4):362-366
Publisher: Elsevier
Issue Date: 2013
ISSN: 1472-6483
1472-6491
Statement of
Responsibility: 
Lobke M. Moolenaar, Seema Mohiuddin, Moira Munro Davie, Margaret A. Merrilees, Frank J.M. Broekmans, Ben Willem J. Mol, Neil P. Johnson
Abstract: Poor ovarian response in IVF cycles is associated with diminished ovarian reserve and poor pregnancy outcome. Little is known about pregnancy outcome after a poor response in women with a normal ovarian reserve. This retrospective study studied women undergoing IVF/intracytoplasmic sperm injection between January 2003 to December 2008 in the FertilityPLUS Clinic in Auckland, New Zealand. All women with a poor response in the first cycle were selected. Primary outcome was live birth after the second cycle. Secondary outcomes were poor response in the second cycle and the predictive values of female age and basal FSH at first cycle and IVF outcome at second cycle. Of the 2487 women starting IVF, 142 women (5.7%) with a poor response in the first cycle were selected, of which 66 (46.5%) women had a repeated poor response in the second cycle. There were 31 live births in the second cycle (21.8%). Female age was the only significant predictor for repeated poor response (AUC 0.69, 95% CI 0.61-0.78) and clinical pregnancy (AUC 0.66, 95% CI 0.57-0.75), but the predictive value was low. Therefore poor response in women with a normal ovarian reserve should not be a reason to discontinue further IVF treatment. Poor ovarian response in IVF cycles is associated with diminished ovarian reserve and poor pregnancy outcome. Little is known about pregnancy outcome after a poor response in women with a normal ovarian reserve. In this retrospective study, we studied women undergoing IVF/intracytoplasmic sperm injection (ICSI) between January 2003 to December 2008 in the FertilityPLUS Clinic in Auckland, New Zealand. All women with a poor response in the first cycle were selected. Primary outcome was live birth after the second cycle. Secondary outcomes were poor response in the second cycle and the predictive value of female age and basal FSH at first cycle and IVF outcome at the second cycle. Of the 2487 women starting wit IVF, a total of 142 women (5.7%) with a poor response in the first cycle were selected, of which 66 (46.5%) women had a repeated poor response in the second cycle. There were 31 live births in the second cycle (22%). Female age was the only significant predictor for repeated poor response and clinical pregnancy, but the predictive value was low. Therefore poor response in women with a normal ovarian reserve should not be a reason to discontinue further IVF treatment.
Keywords: FSH; IVF; life birth; ovarian reserve; poor response
Rights: © 2013, Reproductive Healthcare Ltd.
RMID: 0020136790
DOI: 10.1016/j.rbmo.2013.07.004
Appears in Collections:Obstetrics and Gynaecology publications

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