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Type: Journal article
Title: Ultrasonic heating of the brain of the fetal sheep in utero
Author: Duggan, P.
Liggins, G.
Barnett, S.
Citation: Ultrasound in Medicine and Biology, 1995; 21(4):553-560
Publisher: Pergamon Press
Issue Date: 1995
ISSN: 0301-5629
Statement of
P.M. Duggan, G.C. Liggins, S.B. Barnett
Abstract: The fetal sheep was used as a model to determine the extent of ultrasound-induced heating of brain tissue in procedures involving pulsed Doppler examination of fetal intracranial arteries. Temperature measurements were recorded in late-gestation fetuses insonated in utero. The centre frequency was 3.5 MHz and a pulse repetition rate of 6 to 10 kHz produced a power output of 0.6 or 2 W. The brain was insonated in the near field of a focussed beam where the -6-dB beam width was 1.7 cm for the 0.6-W transducers and 1.2 cm for the 2-W transducers. Mean (standard error) maximal temperature increases of 3.0 degrees C (0.3) and 12.5 degrees C (1.3), respectively, were recorded in dead fetuses. The mean values obtained in normally perfused living fetuses were lower by 43% and 30%, respectively, showing that vascular perfusion substantially limited ultrasonic heating in sheep fetal brain tissue. There were no changes in blood flow to the heated brain tissue as measured using radiolabelled microspheres.
Keywords: Ultrasound
Biological effects
Ultrasound safety
Ultrasonic brain heating
Fetal sheep
DOI: 10.1016/0301-5629(94)00143-2
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Appears in Collections:Aurora harvest 4
Obstetrics and Gynaecology publications

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