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Type: Journal article
Title: Impact of gemcitabine chemotherapy and 3-dimensional conformal radiation therapy/5-fluorouracil on quality of life of patients managed for pancreatic cancer
Author: Short, M.
Goldstein, D.
Halkett, G.
Reece, W.
Borg, M.
Zissiadis, Y.
Kneebone, A.
Spry, N.
Citation: International Journal of Radiation: Oncology - Biology - Physics, 2013; 85(1):157-162
Publisher: Elsevier Science
Issue Date: 2013
ISSN: 0360-3016
Statement of
Michala Short, David Goldstein, Georgia Halkett, William Reece, Martin Borg, Yvonne Zissiadis, Andrew Kneebone, and Nigel Spry
Abstract: <h4>Purpose</h4>To report quality of life (QOL) results for patients receiving chemoradiation therapy for pancreatic cancer.<h4>Methods and materials</h4>Eligible patients (n=41 locally advanced, n=22 postsurgery) entered the B9E-AY-S168 study and received 1 cycle of induction gemcitabine (1000 mg/m2 weekly ×3 with 1-week break) followed by 3-dimensional conformal radiation therapy (RT) (54 Gy locally advanced and 45 Gy postsurgery) and concomitant continuous-infusion 5-fluorouracil (5FU) (200 mg/m2/d throughout RT). After 4 weeks, patients received an additional 3 cycles of consolidation gemcitabine chemotherapy. Patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-PAN26 questionnaires at baseline, before RT/5FU, at end of RT/5FU, before consolidation gemcitabine, and at treatment completion.<h4>Results</h4>The patterns of change in global QOL scores differed between groups. In the locally advanced group global QOL scores were +13, +8, +3, and +1 compared with baseline before RT/5FU (P=.008), at end of RT/5FU, before consolidation gemcitabine, and at treatment completion, respectively. In the postsurgery group, global QOL scores were -3, +4, +15, and +17 compared with baseline at the same time points, with a significant improvement in global QOL before consolidation gemcitabine (P=.03). No significant declines in global QOL were reported by either cohort.<h4>Conclusions</h4>This study demonstrates that global QOL and associated function and symptom profiles for pancreatic chemoradiation therapy differ between locally advanced and postsurgery patients, likely owing to differences in underlying disease status. For both groups, the treatment protocol was well tolerated and did not have a negative impact on patients' global QOL.
Keywords: Humans
Pancreatic Neoplasms
Antimetabolites, Antineoplastic
Radiation-Sensitizing Agents
Treatment Outcome
Radiotherapy, Conformal
Prospective Studies
Quality of Life
Middle Aged
Induction Chemotherapy
Surveys and Questionnaires
Rights: © 2014 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.ijrobp.2012.03.003
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