Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8557
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Type: Journal article
Title: Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate1–3
Author: Lavin, J.
Wittert, G.
Andrews, J.
Yeap, B.
Wishart, J.
Morris, H.
Morley, J.
Horowitz, M.
Read, N.
Citation: American Journal of Clinical Nutrition, 1998; 68(3):591-598
Publisher: AMER SOC CLINICAL NUTRITION
Issue Date: 1998
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Jacquelynne H Lavin, Gary A Wittert, Jane Andrews, Bu Yeap, Judith M Wishart, Howard A Morris, John E Morley, Michael Horowitz, and Nicholas W Read
Abstract: The relation between gastrointestinal incretin hormones in the control of insulin release and short-term satiety by intestinal carbohydrate was investigated in 8 fasted, healthy male volunteers. Insulin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (GLP-1), and appetite ratings were measured during, and food intake was measured after, intraduodenal infusions of glucose or saline. Studies were conducted under hyperinsulinemic and euglycemic conditions. Raising plasma insulin with intravenous insulin infusion to concentrations slightly above usual postprandial concentrations (356.4 +/- 4.8 pmol/L) had no effect on GIP, GLP-1, or appetite ratings before the intraduodenal infusions began. Intraduodenal glucose infusion resulted in a further increase in plasma insulin to a peak of 779.4 +/- 114.0 pmol/L, caused an early increase in plasma GIP and a later increase in GLP-1 concentrations (P < 0.01), suppressed appetite (P < 0.05), and reduced energy intake (P < 0.01) compared with intraduodenal infusion of saline. There was a close association between the increase in GLP-1 and decrease in appetite. Infusion of octreotide to suppress the release of gastrointestinal hormones prevented the rise in insulin, GIP, and GLP-1 induced by intraduodenal glucose infusion and reversed the suppression of appetite and reduction in energy intake. These results suggest that 1) when infused to result in plasma concentrations slightly above usual postprandial concentrations, insulin does not inhibit its own release and 2) the effects of intraduodenal glucose on appetite may be mediated through the release of GLP-1 and not insulin.
Keywords: Humans
Octreotide
Gastric Inhibitory Polypeptide
Glucagon
Insulin
Glucose
Blood Glucose
Peptide Fragments
Protein Precursors
Gastrointestinal Agents
Diet
Infusions, Parenteral
Single-Blind Method
Appetite
Energy Intake
Adult
Male
Glucagon-Like Peptide 1
Rights: © 1998 American Society for Clinical Nutrition
DOI: 10.1093/ajcn/68.3.591
Description (link): http://ajcn.nutrition.org/content/68/3/591.abstract
Published version: http://dx.doi.org/10.1093/ajcn/68.3.591
Appears in Collections:Aurora harvest
Medicine publications

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