Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/85591
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Type: Journal article
Title: Thrombin inhibitors: surgical considerations and pharmacology
Author: Breik, O.
Tadros, R.
Devitt, P.
Citation: Australian and New Zealand Journal of Surgery, 2013; 83(4):215-221
Publisher: Blackwell Science Asia
Issue Date: 2013
ISSN: 0004-8682
1445-1433
Statement of
Responsibility: 
Omar Breik, Rami Tadros and Peter Devitt
Abstract: The new thrombin inhibitors have provided an exciting opportunity for effective thromboprophylaxis without some of the disadvantages of the current anticoagulants. These drugs are orally administered, have predictable pharmacokinetics and dose–response, do not require monitoring and have an acceptable safety profile when used appropriately. However, inappropriate prescribing of these drugs may lead to catastrophic consequences. Clinicians need to be aware of some of the drawbacks associated with the use of dabigatran and, in particular, its reduced clearance in the setting of renal failure and the lack of an effective reversing agent when bleeding does occur. In this review, the evidence for efficacy and safety of dabigatran is discussed. We also aim to provide practical clinical advice on the pre- and post-operative management of the elective and emergency surgical patient on dabigatran and provide guidelines for the management of acute haemorrhage in the context of dabigatran therapy.
Keywords: Bleeding; dabigatran; reversal; thrombin inhibitor; thromboprophylaxis
Description: Article first published online: 6 FEB 2013
Rights: © 2013 The Authors
RMID: 0020137384
DOI: 10.1111/ans.12078
Appears in Collections:Surgery publications

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