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dc.contributor.authorDouglas, R.en
dc.contributor.authorPaton, J.en
dc.contributor.authorDuncan, S.en
dc.contributor.authorHansman, D.en
dc.identifier.citationJournal of Infectious Diseases, 1983; 148(1):131-137en
dc.description.abstractSera were analyzed by radioimmunoassay for type-specific pneumococcal antibody in 249 children aged six to 54 months, who were participating in a controlled trial of a 14-valent pneumococcal vaccine. Levels of serum antibody to all serotypes increased after immunization in all age groups tested. For all serotypes, the antibody response increased progressively with age whether response was viewed as antibody doubling, relative increase in geometric mean, or final antibody level. Responses were poor up to the age of five years for the important pediatric serotypes 6A, 14, 19F, and 23F. Seventeen children under the age of two years at the time of primary immunization received booster doses of vaccine six months later. There was no significant increase in antibody to any serotype, and the geometric mean antibody levels fell for most types. Immune response to the pediatric serotypes was poor until the age of 4.5 years.en
dc.description.statementofresponsibilityR. M. Douglas, J. C. Paton, S. J. Duncan and D. J. Hansmanen
dc.publisherOxford University Pressen
dc.rights© 1983 by The University of Chicagoen
dc.subjectHumans; Streptococcus pneumoniae; Pneumococcal Infections; Bacterial Vaccines; Pneumococcal Vaccines; Antibodies, Bacterial; Placebos; Immunization, Secondary; Dose-Response Relationship, Immunologic; Aging; Time Factors; Child, Preschool; Infanten
dc.titleAntibody response to pneumococcal vaccination in children younger than five years of ageen
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]en
Appears in Collections:Molecular and Biomedical Science publications

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