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dc.contributor.authorDouglas, R.en
dc.contributor.authorHansman, D.en
dc.contributor.authorMiles, H.en
dc.contributor.authorPaton, J.en
dc.identifier.citationAmerican Journal of Diseases of Children, 1986; 140(11):1183-1185en
dc.description.abstractNo consistent effect on nasal carriage rates of Streptococcus pneumoniae belonging to vaccine types was observed during a randomized, controlled trial of a 14-valent pneumococcal vaccine, which included 1273 Australian children aged 6 to 54 months. Nasal carriage of S pneumoniae was associated with a significantly elevated homotypic serum antibody concentration for types 18C, 19F, and 23F, but not for types 6A and 14 (these five types are the most important causes of pneumococcal infections in children). Upper respiratory tract carriage seems to play an important role in natural acquisition of antibody to some but not all pneumococcal serotypes. These findings help to explain why pneumococcal vaccine fails to protect young children from acute otitis media.en
dc.description.statementofresponsibilityRobert M. Douglas, David Hansman, Helen B. Miles, James C. Patonen
dc.publisherAmerican Medical Associationen
dc.rightsCopyright status unknownen
dc.subjectNose; Humans; Streptococcus pneumoniae; Bacterial Vaccines; Pneumococcal Vaccines; Antibodies, Bacterial; Serotyping; Double-Blind Method; Random Allocation; Child, Preschool; Infant; Clinical Trials as Topicen
dc.titlePneumococcal carriage and type-specific antibody: failure of a 14-valent vaccine to reduce carriage in healthy childrenen
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]en
Appears in Collections:Molecular and Biomedical Science publications

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