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Type: Journal article
Title: Differences in the regulation of aldehyde dehydrogenase genes in Aspergillus niger and Aspergillus nidulans
Author: O'Connell, M.
Kelly, J.
Citation: Current Genetics: lower eukaryotes and organelles, 1988; 14(2):95-103
Publisher: Springer-Verlag
Issue Date: 1988
ISSN: 0172-8083
Statement of
Matthew J. O'Connell, Joan M. Kelly
Abstract: In order to study mechanisms of gene regulation in A. niger, and to compare these to similar systems in A. nidulans, a gene encoding an aldehyde dehydrogenase enzyme has been cloned. In wild-type strains of A. niger the gene shows expression which is regulated by induction and repression. Levels of induction by various compounds and the extent of repression under various growth conditions differs from that seen for the A. nidulans aldA gene. Unlike the A. nidulans aldA gene, the A. niger gene has both carbon catabolite repressible and nonrepressible induction mechanisms. Studies of heterologous expression of the A. niger gene in A. nidulans have shown that its expression is regulated by the alcR gene product of A. nidulans.
Keywords: Aldehyde dehydrogenase
Gene regulation
Heterologous expression
Rights: © Springer-Verlag 1988
DOI: 10.1007/BF00569332
Appears in Collections:Aurora harvest 2
Genetics publications

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