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Type: Journal article
Title: Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae
Author: Paton, J.
Lock, R.
Hansman, D.
Citation: Infection and Immunity, 1983; 40(2):548-552
Publisher: American Society for Microbiology
Issue Date: 1983
ISSN: 0019-9567
Statement of
James C. Paton, Robert A. Lock, and David J. Hansman
Abstract: The role of the cytolytic toxin pneumolysin in the pathogenicity of Streptococcus pneumoniae was investigated. Pneumolysin was purified to homogeneity and used to immunize mice. When these mice were subsequently challenged via the nasal route with virulent S. pneumoniae, they survived significantly longer than control mice. The mean survival times were 5.52 and 2.48 days for immunized and control mice, respectively. This work provides direct evidence for the involvement of pneumolysin in pneumococcal pathogenicity.
Keywords: Animals; Mice; Streptococcus pneumoniae; Pneumococcal Infections; Bacterial Proteins; Streptolysins; Antibodies, Bacterial; Immunization
Rights: © 1983, American Society for Microbiology
RMID: 0030008958
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Appears in Collections:Molecular and Biomedical Science publications

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