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Type: Journal article
Title: Tailored immune responses: novel effector helper T cell subsets in protective immunity
Author: Kara, E.
Comerford, I.
Fenix, K.
Bastow, C.
Gregor, C.
McKenzie, D.
McColl, S.
Citation: PLoS Pathogens, 2014; 10(2):1003905-1-1003905-15
Publisher: Public Library of Science
Issue Date: 2014
ISSN: 1553-7374
Statement of
Ervin E. Kara, Iain Comerford, Kevin A. Fenix, Cameron R. Bastow, Carly E. Gregor, Duncan R. McKenzie, Shaun R. McColl
Abstract: Differentiation of naïve CD4+ cells into functionally distinct effector helper T cell subsets, characterised by distinct “cytokine signatures,” is a cardinal strategy employed by the mammalian immune system to efficiently deal with the rapidly evolving array of pathogenic microorganisms encountered by the host. Since the TH1/TH2 paradigm was first described by Mosmann and Coffman, research in the field of helper T cell biology has grown exponentially with seven functionally unique subsets having now been described. In this review, recent insights into the molecular mechanisms that govern differentiation and function of effector helper T cell subsets will be discussed in the context of microbial infections, with a focus on how these different helper T cell subsets orchestrate immune responses tailored to combat the nature of the pathogenic threat encountered.
Keywords: T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Animals; Humans; Cell Differentiation; Adaptive Immunity
Rights: © 2014 Kara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020136401
DOI: 10.1371/journal.ppat.1003905
Grant ID:
Appears in Collections:Molecular and Biomedical Science publications

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