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|Title:||Multilineage involvement and erythropietin - "independent" erythroid progenitor cells in a patient with systemic mastrocytosis|
Ashman, Leonie Kay
|Citation:||Annals of Hematology, 1998; 77(4):183-186|
|O. Afonja, E. Amorosi, L. Ashman, K. Takeshita|
|Abstract:||We report on a patient with systemic mastocytosis with an activating point mutation of the c-kit gene. This mutation was identical to the c-kit mutation recently described by other groups. Additionally, we found that in this patient the mutation was also present in myeloid and erythroid lineages, indicating a multilineage involvement and suggesting a clonal origin of the disease similar to that described in other myeloproliferative disorders. The erythroid involvement was further demonstrated by the presence of erythropoietin-"independent" erythroid progenitor cells.|
|Keywords:||Key words c-kit gene; Mutation; Tyrosine kinase|
|Rights:||© Springer-Verlag 1998|
|Appears in Collections:||Medicine publications|
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