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Type: Journal article
Title: Multilineage involvement and erythropietin - "independent" erythroid progenitor cells in a patient with systemic mastrocytosis
Author: Afonja, O.
Amorosi, E.
Ashman, Leonie Kay
Takeshita, K.
Citation: Annals of Hematology, 1998; 77(4):183-186
Issue Date: 1998
ISSN: 0939-5555
Statement of
O. Afonja, E. Amorosi, L. Ashman, K. Takeshita
Abstract: We report on a patient with systemic mastocytosis with an activating point mutation of the c-kit gene. This mutation was identical to the c-kit mutation recently described by other groups. Additionally, we found that in this patient the mutation was also present in myeloid and erythroid lineages, indicating a multilineage involvement and suggesting a clonal origin of the disease similar to that described in other myeloproliferative disorders. The erythroid involvement was further demonstrated by the presence of erythropoietin-"independent" erythroid progenitor cells.
Keywords: Key words c-kit gene; Mutation; Tyrosine kinase
Rights: © Springer-Verlag 1998
DOI: 10.1007/s002770050439
Appears in Collections:Medicine publications

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