Please use this identifier to cite or link to this item:
|Title:||Improved quality of life with megasterol acetate in patients with endocrine-insensitive advanced cancer.|
Levi, J. A.
Olver, Ian N.
Simes, R. J.
|Citation:||Annals of Oncology, 1997; 8(3):277-283|
|E. Beller, M. Tattersall, T. Lumley, J. Levi, D. Dalley, I. Olver, J. Page, E. Abdi, C. Wynne, M. Friedlander, D. Boadle, H. Wheeler, S. Margrie, R. J. Simes, and Australasian Megestrol Acetate Cooperative Study Group|
|Abstract:||Purpose: To investigate the effect of two doses of megestrol acetate (MA) compared with placebo on quality of life (QoL) and nutritional status (NS) in patients with advanced endo crine-insensitive cancer. Patients and methods: Two hundred forty patients were randomised to double-blind MA 480 mg/day, MA 160 mg/day, or matching placebo for 12 weeks. Nutritional status (including weight, skinfold thickness and midarm circumference) and QoL (using 6 linear analogue self-assessment (LASA) scales) were assessed at randomisation and after four, eight and 12 weeks. A QoL ranking incorporating QoL and death was also used ranging from 1 = dead to 5 = much better QoL. Results: One hundred seventy-four patients were assessable at week four, 136 at week eight and 103 patients at week 12. Patients receiving MA reported substantially better appetite (P = 0.001), mood (P = 0.001) and overall quality of life (P < 0.001), and possibly less nausea and vomiting (P = 0.08) than patients receiving placebo, based on a test for trend. A larger benefit was seen with the higher dose which (unlike the lower dose) was significantly better in pairwise comparisons with placebo for appetite, mood and overall QoL (each P ≤0.001). Despite some missing data on QoL scores, QoL ranking was available on 227 (95%) of patients with significantly higher QoL ranking associated with MA (P =0.002). Improve ments in QoL occurred early within four weeks and were sustained. No statistically significant differences were observed in NS measurements, including weight (P =0.29). Side effects of therapy were minor and did not differ significantly across treatments. Conclusion: Megestrol acetate given at 480 mg/day is useful palliation in patients with endocrine-insensitive advanced cancer. It improves appetite, mood and overall quality of life in these patients, although not through a direct effect on nutritional status.|
|Keywords:||cachexia; megestrol acetate; quality of life|
|Rights:||© 1997 Kluwer Academic Publishers|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.