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https://hdl.handle.net/2440/86166
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Type: | Journal article |
Title: | Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation |
Author: | Gregori, S. Bacchetta, R. Hauben, E. Battaglia, M. Roncarolo, M. |
Citation: | Current Opinion in Hematology, 2005; 12(6):451-456 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2005 |
ISSN: | 1065-6251 1531-7048 |
Statement of Responsibility: | Silvia Gregori, Rosa Bacchetta, Ehud Hauben, Manuela Battaglia and Maria-Grazia Roncarolo |
Abstract: | Purpose of review: Regulatory T cells exert a dominant effect in controlling autoimmunity and maintaining peripheral tolerance. Regulatory T cells are also involved in preventing allograft rejection and graft versus host disease. Cellular therapy with expanded regulatory T cells represents a promising approach to control T-cell mediated pathology. In this review we will summarize the efforts to design new methods for expanding regulatory T cells and exploit their regulatory function as cellular therapy for the treatment of graft versus host disease after hematopoietic stem cell transplantation. Recent findings: Among CD4+ T cells, the best described are the naturally occurring CD4+CD25+ regulatory T cells and type 1 regulatory T cells. Recent progress has been made in the characterization of both subsets in terms of isolation and induction, respectively. However, a clear definition of their mechanisms of action has still to be achieved. Summary: Better understanding of the mechanisms of suppression mediated by regulatory T cells might enable their use to modulate specific immune responses. Moreover, the recent development of methods allowing the ex-vivo expansion of regulatory T cells, to provide sufficient number of cells for in-vivo infusion, represents the first step toward the use of these cells as cellular therapy for the treatment of immunologic and hematological diseases. |
Keywords: | cellular therapy; CD4+CD25+; regulatory T cells; graft versus host disease; hematopoietic stem cell transplantation; type 1 regulatory T cells |
Rights: | © 2005 Lippincott Williams & Wilkins, Inc. |
DOI: | 10.1097/01.moh.0000177826.41262.0a |
Published version: | http://www.ncbi.nlm.nih.gov/pubmed/16217161 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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