Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/86214
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Type: Journal article
Title: Start of induction of labour with oxytocin in the morning or in the evening. A randomised controlled trial
Author: Bakker, J.
De Vos, R.
Pel, M.
Wisman, C.
van Lith, J.
Mol, B.
van der Post, J.
Citation: BJOG: an International Journal of Obstetrics and Gynaecology, 2009; 116(4):562-568
Publisher: Wiley
Issue Date: 2009
ISSN: 1470-0328
1471-0528
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Responsibility: 
JJ Bakker, R De Vos, M Pel, C Wisman, JM Van Lith, BWJ Mol, JA Van Der Post
Abstract: Objective:  The objective of this study was to compare outcomes of induced labour with intravenous oxytocin with a start in the evening versus in the morning. Design:  Randomised controlled trial. Setting:  Labour wards of three hospitals in Amsterdam, the Netherlands. Participants:  Women with an indication for induction of labour with intravenous oxytocin. Methods:  Included women were randomized to either the evening group with a start of induction of labour at 21:00 hours, or the morning group with a start at 07:00 hours. Main outcome measures:  Primary outcome was duration of labour. Secondary outcomes were instrumental delivery rate, adverse neonatal outcome defined as an Apgar score below 7 after 5 minutes, number and indications of paediatric consults and neonatal admissions, duration of second stage, number of intrapartum infections and necessity of pain relief. Results:  We randomised 371 women. Mean duration of labour was not significantly different (primiparae: morning 12 hours and 8 minutes versus evening 11 hours and 22 minutes, P value 0.29; multiparae: morning 7 hours and 34 minutes versus evening 7 hours and 46 minutes, P value 0.70). There were no significant differences in instrumental deliveries rates, number of infections or patient satisfaction. Unexpectedly, neonatal outcome was better in women induced in the evening. Conclusion:  Induction of labour with intravenous oxytocin in the evening is equally effective as induction in the morning.
Keywords: Circadian rhythm; duration of labour; induced labour; oxytocin
Description: Article first published online: 18 FEB 2009
Rights: © 2009 The Authors
DOI: 10.1111/j.1471-0528.2008.02102.x
Appears in Collections:Aurora harvest 7
Obstetrics and Gynaecology publications

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