Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/86514
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Type: Journal article
Title: Therapeutic options for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review
Author: Bright, R.
Wilkinson, J.
Coventry, B.
Citation: BMC Neurology, 2014; 14(1):26-1-26-9
Publisher: BioMed Central
Issue Date: 2014
ISSN: 1471-2377
1471-2377
Statement of
Responsibility: 
Richard J Bright, Jenny Wilkinson and Brendon J Coventry
Abstract: Background: Chronic inflammatory demyelinating polyradiculoneuropathy is a rare acquired immune-mediated progressive or relapsing disorder causing peripheral neuropathic disease of duration more than two months. Many individuals with chronic inflammatory demyelinating polyradiculoneuropathy fail to make a long-term recovery with current treatment regimes. The aim of this study was to prospectively review the literature to determine the effectiveness of therapies for chronic inflammatory demyelinating polyradiculoneuropathy. Methods: Articles published from January 1990 to December 2012 were searched for studies to treat adults with chronic inflammatory demyelinating polyradiculoneuropathy. Peer-reviewed full-text articles published in English were included. Results: Nine placebo-controlled double-blinded randomised trials were reviewed to treat subjects with chronic inflammatory demyelinating polyradiculoneuropathy exhibiting various degrees of effectiveness. The most effect treatments were; three randomised controlled trials using intravenous immunoglobulin, a study comparing pulsed dexamethasone and short term prednisolone and rituximab all showed promising results and were well tolerated. Conclusion: IVIg and corticosteroids remain first line treatments for CIDP. Therapies using monoclonal antibodies, such as Rituximab and Natalizumab offer the most promise for treatment of Chronic inflammatory demyelinating polyradiculoneuropathy however they also need further research, as does the use of stem cell therapy for treating Chronic inflammatory demyelinating polyradiculoneuropathy. Large randomised controlled trials and better patient selection are required to address responsiveness of CIDP patients to conventional treatments to elucidate mechanisms of action and future directions for therapeutic improvement.
Keywords: Chronic inflammatory demyelinating polyneuropathy; Peripheral neuropathy; Anti-myelin associated glycoprotein; Autoimmune diseases; Treatment; Plasmapheresis; IVIg; Corticosteroids
Rights: © 2014 Bright et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
RMID: 0020135739
DOI: 10.1186/1471-2377-14-26
Appears in Collections:Dentistry publications

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