Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/86652
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Type: Journal article
Title: Balloon dilation of the esophago-gastric junction affects lower and upper esophageal sphincter function in achalasia
Author: Wauters, L.
Van Oudenhove, L.
Selleslagh, M.
Vanuytsel, T.
Boeckxstaens, G.
Tack, J.
Omari, T.
Rommel, N.
Citation: Neurogastroenterology and Motility, 2014; 26(1):69-76
Publisher: John Wiley & Sons
Issue Date: 2014
ISSN: 1350-1925
1365-2982
Statement of
Responsibility: 
L. Wauters, L. Van Oudenhove, M. Selleslagh, T. Vanuytsel, G. Boeckxstaens, J. Tack, T. Omari and N. Rommel
Abstract: Background: Pneumatic dilation of the lower esophageal sphincter (LES) in achalasia has an unappreciated effect on upper esophageal sphincter (UES) function. We studied UES pressure patterns at baseline and alterations in UES parameters resulting from therapy. Methods: High-resolution manometry (HRM) tracings from 50 achalasia patients, seen at a tertiary center between January 2009 and July 2011, were reviewed. Manometric parameters studied were (i) LES: resting pressure (restP), 4-second integrated relaxation pressure (IRP4); (ii) UES: resting pressure (restP), minimal relaxation pressure (MRP), peak pressure (PP), relaxation interval (RI), intrabolus pressure (IBP), and deglutitive sphincter resistance (DSR). Mixed models analyses with LES and UES parameters as dependent variables and treatment stage as within-subject independent variable of interest were used. Correlations between treatment-induced changes in LES, UES, and esophageal body (EB) parameters were performed. Key Results: Pre- and posttreatment HRM tracings were available from 50 patients (mean age 52.7 ± 18.6 years, 29 men). Upper esophageal sphincter parameters MRP (17.9 ± 1.2 vs 15.2 ± 0.9 mmHg; p = 0.02) and IBP (31.5 ± 1.5 vs 27.4 ± 1.2 mmHg; p = 0.009) were significantly reduced after initial balloon dilation and this effect was significant in type II achalasia (p = 0.002 and p = 0.0006). Peak pressure, RI, and DSR were not. The therapeutic effect on LES IRP4 correlated significantly with the change in UES MRP, statistically mediated by the change in EB deglutitive pressure (p = 0.004 and p = 0.0002). Conclusions & Inferences: We present the first HRM study demonstrating that pneumatic dilation of the LES affects intraesophageal and UES pressures in patients with achalasia.
Keywords: Achalasia; dilatation; high-resolution manometry; upper esophageal sphincter
Rights: © 2013 John Wiley & Sons Ltd
RMID: 0020134313
DOI: 10.1111/nmo.12228
Appears in Collections:Paediatrics publications

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