Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/86734
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Type: Journal article
Title: Interaction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib
Author: Eadie, L.
Hughes, T.
White, D.
Citation: Clinical Pharmacology and Therapeutics, 2014; 95(3):294-306
Publisher: Mosby
Issue Date: 2014
ISSN: 0009-9236
1532-6535
Statement of
Responsibility: 
L N Eadie, T P Hughes and D L White
Abstract: The efflux transporters adenosine triphosphate (ATP)-binding cassette (ABC)B1 and ABCG2 have been demonstrated to interact with the tyrosine kinase inhibitors (TKIs) imatinib, nilotinib, and dasatinib. However, although some studies conclude that TKIs are substrates of one or both transporters, other studies demonstrate only an inhibitory function. This variation is probably due to differences in the concentration of TKIs assayed and the experimental systems used. This article examines the evidence for clinically relevant interactions between three currently approved TKIs and ABCB1/ABCG2.
Keywords: Animals
Humans
Benzamides
Piperazines
Pyrimidines
Thiazoles
ATP-Binding Cassette Transporters
Neoplasm Proteins
Enzyme Inhibitors
Protein-Tyrosine Kinases
Imatinib Mesylate
Dasatinib
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Rights: © 2014 American Society for Clinical Pharmacology and Therapeutics
DOI: 10.1038/clpt.2013.208
Appears in Collections:Aurora harvest 2
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