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dc.contributor.authorToal, M.-
dc.contributor.authorKeating, S.-
dc.contributor.authorMachin, G.-
dc.contributor.authorDodd, J.-
dc.contributor.authorAdamson, S.L.-
dc.contributor.authorWindrim, R.C.-
dc.contributor.authorKingdom, J.C.-
dc.identifier.citationAmerican Journal of Obstetrics and Gynecology, 2008; 198(3):330.e1-330.e7-
dc.description.abstractObjective: The purpose of this study was to evaluate the prognostic role of placental ultrasound imaging at 19-23 weeks of gestation in clinically high-risk women with abnormal uterine artery Doppler (UTAD). Study Design: Placentas of 60 women with abnormal UTAD were examined at 19-23 weeks of gestation for shape and texture abnormalities. Findings were correlated with clinical outcomes (preterm delivery at <32 weeks of gestation; birth weight <10th percentile [small for gestational age]; preeclampsia/hemolysis, elevated liver enzymes, low platelets; early-onset intrauterine growth restriction with abnormal umbilical artery Doppler; and intrauterine fetal death) and maternal serum screening data. Placental disease was reviewed by 2 perinatal pathologists. Results: Women with abnormal placental shape at 19-23 weeks of gestation (n = 28) had higher odds of intrauterine fetal death (odds ratio, 4.5; 95% CI, 1.3-15.6), delivery at <32 weeks of gestation (odds ratio, 4.7; 95% CI, 1.6-14.1]), and intrauterine growth restriction (odds ratio, 4.7; 95% CI, 1.4-15.1]) than did the women with a normal placental shape. Thirty-two of 41 placentas (74%) weighed <10th percentile, and 36 of 43 placentas (83%) had ischemic-thrombotic pathologic condition. There was no association between abnormal placental shape at 19-23 weeks of gestation and placental weight, but 5 of 6 placentas that were <10 cm long were <10th percentile for weight at delivery. There was a poor correlation between measures of ultrasound texture at 19-23 weeks of gestation and the presence of specific lesions at delivery. Conclusion: Combined abnormal UTAD and placental dysmorphologic condition before fetal viability identifies a subset of women who are at risk of adverse outcomes. Placental size is critical in the determination of the outcome in this situation because of the very high prevalence of destructive lesions, although present methods of placental imaging have significant limitations.-
dc.description.statementofresponsibilityMeghana Toal, Sarah Keating, Geoff Machin, Jodie Dodd, S. Lee Adamson, Rory C. Windrim, John C. P. Kingdom-
dc.rightsCopyright © 2008 Mosby, Inc. All rights reserved.-
dc.subjectperinatal outcome; placental morphologic condition; placental disease; pregnancy; uterine artery Doppler imaging-
dc.titleDeterminants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler images-
dc.typeJournal article-
dc.identifier.orcidDodd, J. [0000-0002-6363-4874]-
Appears in Collections:Aurora harvest 2
Paediatrics publications

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