Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8696
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Type: Journal article
Title: Granulocyte colony-stimulating factor (G-CSF) dose-dependent efficacy in peripheral blood stem cell mobilisation in patients who had failed initial mobilization with chemotherapy and G-CSF
Author: Lie, A.
Hui, C.
Rawling, T.
Dyson, P.
Thorp, D.
Benic, J.
Rawling, C.
Toogood, I.
Harvath, N.
Simmons, P.
To, L.
Citation: Bone Marrow Transplantation, 1998; 22(9):853-857
Publisher: STOCKTON PRESS
Issue Date: 1998
ISSN: 0268-3369
1476-5365
Abstract: For 10 consecutive patients in our unit who did not show a significant rise in blood progenitor cells within 14 days following chemotherapy and G-CSF, we increased the G-CSF dose from 5 to 10 microg/kg/day (n = 9) or from 10 to 15 microg/kg/day (n = 1). As a result, there were significant increases in total yield as well as yield per apheresis of mononuclear cells, CD34+ cells and CFU-GM (P < 0.025, <0.01 and <0.005, respectively). After G-CSF dose escalation, six of the 10 patients had sufficient CD34+ cells for performing transplantation. These results demonstrate a dose-dependent response of progenitor cell mobilization by G-CSF when used in combination with chemotherapy. Moreover, increasing the dose of G-CSF as late as the third week of mobilization may still provide sufficient cell yield even with patients who did not show a significant mobilization with conventional doses of G-CSF.
Keywords: Humans
Neoplasms
Granulocyte Colony-Stimulating Factor
Antineoplastic Combined Chemotherapy Protocols
Hematopoietic Stem Cell Mobilization
Combined Modality Therapy
Hematopoietic Stem Cell Transplantation
Transplantation, Autologous
Dose-Response Relationship, Drug
Adolescent
Adult
Aged
Middle Aged
Child
Child, Preschool
DOI: 10.1038/sj.bmt.1701463
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