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|Title:||Granulocyte colony-stimulating factor (G-CSF) dose-dependent efficacy in peripheral blood stem cell mobilisation in patients who had failed initial mobilization with chemotherapy and G-CSF|
|Citation:||Bone Marrow Transplantation, 1998; 22(9):853-857|
|Abstract:||For 10 consecutive patients in our unit who did not show a significant rise in blood progenitor cells within 14 days following chemotherapy and G-CSF, we increased the G-CSF dose from 5 to 10 microg/kg/day (n = 9) or from 10 to 15 microg/kg/day (n = 1). As a result, there were significant increases in total yield as well as yield per apheresis of mononuclear cells, CD34+ cells and CFU-GM (P < 0.025, <0.01 and <0.005, respectively). After G-CSF dose escalation, six of the 10 patients had sufficient CD34+ cells for performing transplantation. These results demonstrate a dose-dependent response of progenitor cell mobilization by G-CSF when used in combination with chemotherapy. Moreover, increasing the dose of G-CSF as late as the third week of mobilization may still provide sufficient cell yield even with patients who did not show a significant mobilization with conventional doses of G-CSF.|
|Keywords:||Humans; Neoplasms; Granulocyte Colony-Stimulating Factor; Antineoplastic Combined Chemotherapy Protocols; Hematopoietic Stem Cell Mobilization; Combined Modality Therapy; Hematopoietic Stem Cell Transplantation; Transplantation, Autologous; Dose-Response Relationship, Drug; Adolescent; Adult; Aged; Middle Aged; Child; Child, Preschool|
|Appears in Collections:||Medicine publications|
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