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https://hdl.handle.net/2440/8696
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Type: | Journal article |
Title: | Granulocyte colony-stimulating factor (G-CSF) dose-dependent efficacy in peripheral blood stem cell mobilisation in patients who had failed initial mobilization with chemotherapy and G-CSF |
Author: | Lie, A. Hui, C.H. Rawling, T. Dyson, P. Thorp, D. Benic, J. Rawling, C. Toogood, I. Harvath, N. Simmons, P. To, L. |
Citation: | Bone Marrow Transplantation, 1998; 22(9):853-857 |
Publisher: | STOCKTON PRESS |
Issue Date: | 1998 |
ISSN: | 0268-3369 1476-5365 |
Abstract: | For 10 consecutive patients in our unit who did not show a significant rise in blood progenitor cells within 14 days following chemotherapy and G-CSF, we increased the G-CSF dose from 5 to 10 microg/kg/day (n = 9) or from 10 to 15 microg/kg/day (n = 1). As a result, there were significant increases in total yield as well as yield per apheresis of mononuclear cells, CD34+ cells and CFU-GM (P < 0.025, <0.01 and <0.005, respectively). After G-CSF dose escalation, six of the 10 patients had sufficient CD34+ cells for performing transplantation. These results demonstrate a dose-dependent response of progenitor cell mobilization by G-CSF when used in combination with chemotherapy. Moreover, increasing the dose of G-CSF as late as the third week of mobilization may still provide sufficient cell yield even with patients who did not show a significant mobilization with conventional doses of G-CSF. |
Keywords: | Humans Neoplasms Granulocyte Colony-Stimulating Factor Antineoplastic Combined Chemotherapy Protocols Hematopoietic Stem Cell Mobilization Combined Modality Therapy Hematopoietic Stem Cell Transplantation Transplantation, Autologous Dose-Response Relationship, Drug Adolescent Adult Aged Middle Aged Child Child, Preschool |
DOI: | 10.1038/sj.bmt.1701463 |
Published version: | http://dx.doi.org/10.1038/sj.bmt.1701463 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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