Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/8696
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dc.contributor.authorLie, A.-
dc.contributor.authorHui, C.H.-
dc.contributor.authorRawling, T.-
dc.contributor.authorDyson, P.-
dc.contributor.authorThorp, D.-
dc.contributor.authorBenic, J.-
dc.contributor.authorRawling, C.-
dc.contributor.authorToogood, I.-
dc.contributor.authorHarvath, N.-
dc.contributor.authorSimmons, P.-
dc.contributor.authorTo, L.-
dc.date.issued1998-
dc.identifier.citationBone Marrow Transplantation, 1998; 22(9):853-857-
dc.identifier.issn0268-3369-
dc.identifier.issn1476-5365-
dc.identifier.urihttp://hdl.handle.net/2440/8696-
dc.description.abstractFor 10 consecutive patients in our unit who did not show a significant rise in blood progenitor cells within 14 days following chemotherapy and G-CSF, we increased the G-CSF dose from 5 to 10 microg/kg/day (n = 9) or from 10 to 15 microg/kg/day (n = 1). As a result, there were significant increases in total yield as well as yield per apheresis of mononuclear cells, CD34+ cells and CFU-GM (P < 0.025, <0.01 and <0.005, respectively). After G-CSF dose escalation, six of the 10 patients had sufficient CD34+ cells for performing transplantation. These results demonstrate a dose-dependent response of progenitor cell mobilization by G-CSF when used in combination with chemotherapy. Moreover, increasing the dose of G-CSF as late as the third week of mobilization may still provide sufficient cell yield even with patients who did not show a significant mobilization with conventional doses of G-CSF.-
dc.language.isoen-
dc.publisherSTOCKTON PRESS-
dc.subjectHumans-
dc.subjectNeoplasms-
dc.subjectGranulocyte Colony-Stimulating Factor-
dc.subjectAntineoplastic Combined Chemotherapy Protocols-
dc.subjectHematopoietic Stem Cell Mobilization-
dc.subjectCombined Modality Therapy-
dc.subjectHematopoietic Stem Cell Transplantation-
dc.subjectTransplantation, Autologous-
dc.subjectDose-Response Relationship, Drug-
dc.subjectAdolescent-
dc.subjectAdult-
dc.subjectAged-
dc.subjectMiddle Aged-
dc.subjectChild-
dc.subjectChild, Preschool-
dc.titleGranulocyte colony-stimulating factor (G-CSF) dose-dependent efficacy in peripheral blood stem cell mobilisation in patients who had failed initial mobilization with chemotherapy and G-CSF-
dc.typeJournal article-
dc.identifier.doi10.1038/sj.bmt.1701463-
pubs.publication-statusPublished-
Appears in Collections:Aurora harvest 4
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