Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87006
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Type: Journal article
Title: Silica materials in drug delivery applications
Author: Simovic, S.
Ghouchi-Eskandar, N.
Sinn, A.
Losic, D.
Prestidge, C.
Citation: Current Drug Discovery Technologies, 2011; 8(3):250-268
Publisher: Bentham Science Publishers
Issue Date: 2011
ISSN: 1570-1638
1875-6220
Statement of
Responsibility: 
Spomenka Simovic, Nasrin Ghouchi-Eskandar, Aw Moom Sinn, Dusan Losic and Clive A. Prestidge
Abstract: In this review article we collect and analyse preparation, chemistry and properties of silica materials relevant for drug delivery applications. We review some of the most relevant milestones in the research of silica materials for implantable, oral, intravenous and dermal drug delivery systems. Preparation, chemistry and drug delivery characteristics of fumed silica nanoparticles (oral and dermal delivery route), silica xerogels (implant delivery), mesoporous silica materials (implant and oral delivery) and mesoporous silica spheres (intravenous delivery) with particular emphasis on their role in anticancer therapy and the design of stimuli responsive drug delivery systems are analysed. Recent progress in the research of silica materials for controlled drug delivery, namely, biocompatibility aspects, research on hybrid materials, anticancer and stimuli-responsive mesoporous silica materials are particularly emphasized.
Keywords: Animals; Humans; Neoplasms; Silicon Dioxide; Antineoplastic Agents; Delayed-Action Preparations; Drug Implants; Drug Carriers; Drug Delivery Systems; Porosity; Nanoparticles
Rights: Copyright status unknown
RMID: 0020128269
DOI: 10.2174/157016311796799026
Appears in Collections:Chemical Engineering publications

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