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Type: Journal article
Title: Mammalian target of rapamycin inhibitor-associated stomatitis
Author: Boers-Doets, C.
Raber-Durlacher, J.
Treister, N.
Epstein, J.
Arends, A.
Wiersma, D.
Lalla, R.
Logan, R.
van Erp, N.
Gelderblom, H.
Citation: Future Oncology, 2013; 9(12):1883-1892
Publisher: Future Medicine
Issue Date: 2013
ISSN: 1479-6694
Statement of
Christine B Boers-Doets, Judith E Raber-Durlacher, Nathaniel S Treister, Joel B Epstein, Anniek BP Arends, Diede R Wiersma, Rajesh V Lalla, Richard M Logan, Nielka P van Erp, Hans Gelderblom
Abstract: With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been identified. In fact, stomatitis and rash are documented as the most frequent and potentially dose-limiting side effects. Clinically, mTOR inhibitor-associated stomatitis (mIAS) more closely resembles aphthous stomatitis than oral mucositis due to conventional anticancer therapies. While most cases of mIAS are mild to moderate and self-limiting, more severe and persistent mIAS can become a dose-limiting toxicity. Small ulcerations may cause significant pain and mucosal sensitivity may occur in the absence of clinical changes. Use of clinical assessment tools that are primarily driven by ulceration size may underestimate mIAS, and assessment should include patient-reported outcomes. This article provides an up-to-date review of the clinical presentation, terminology, pathogenesis, assessment and management of mIAS and other mTOR inhibitor-associated oral adverse events. In addition, areas of future research are considered.
Keywords: mTOR; mTOR inhibitor-associated stomatitis; oral mucositis; stomatitis; targeted therapy
Rights: © CB Boers-Doets
RMID: 0030010777
DOI: 10.2217/FON.13.141
Appears in Collections:Dentistry publications

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