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https://hdl.handle.net/2440/8705
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dc.contributor.author | Hughes, T. | - |
dc.contributor.author | Grigg, A. | - |
dc.contributor.author | Szer, J. | - |
dc.contributor.author | Ho, J. | - |
dc.contributor.author | Ma, D. | - |
dc.contributor.author | Dale, B. | - |
dc.contributor.author | Green, R. | - |
dc.contributor.author | Norman, J. | - |
dc.contributor.author | Sage, R. | - |
dc.contributor.author | Herrmann, R. | - |
dc.contributor.author | Cannell, P. | - |
dc.contributor.author | Schwarer, A. | - |
dc.contributor.author | Taylor, K. | - |
dc.contributor.author | Atkinson, K. | - |
dc.contributor.author | Arthur, C. | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | British Journal of Haematology, 1997; 96(3):635-640 | - |
dc.identifier.issn | 0007-1048 | - |
dc.identifier.issn | 1365-2141 | - |
dc.identifier.uri | http://hdl.handle.net/2440/8705 | - |
dc.description.abstract | Mobilization of Philadelphia chromosome (Ph) negative blood progenitors was attempted in 23 newly diagnosed chronic myeloid leukaemia (CML) patients using a regimen of cyclophosphamide (CY) 5 g/m² and rHUG-CSF 150 μg/m² daily. This regimen was well tolerated with no major adverse events reported. More than 2 × 10⁶/kg CD34⁺ cells were collected in 21 patients (91%). Predominantly Ph-negative mobilization (0–25% Ph-positive) was seen in 30% of cases overall and was confined to patients with a Sokal prognostic score < 1 (7/11 with Sokal score <1; 0/12 with Sokal score ≥1). Within the low Sokal index group, a low WBC count pre-mobilization and a low WBC nadir both correlated strongly with Ph-negative mobilization (P =0.006 and 0.02 respectively). Five of 19 patients receiving at least 6 months of Roferon A therapy post mobilization achieved a major cytogenetic response; all five patients were Ph-negative mobilizers. Therefore CML patients can be divided into a good-prognosis group in whom predominantly Ph-negative progenitors can be mobilized using a regimen of moderate intensity if haematological control is achieved pre-mobilization, and a poor-prognosis group for whom predominantly Ph-positive cells are mobilized with this regimen regardless of haematological control. | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing | - |
dc.source.uri | http://www3.interscience.wiley.com/journal/119164513/abstract | - |
dc.subject | Hematopoietic Stem Cells | - |
dc.subject | Humans | - |
dc.subject | Leukemia, Myeloid, Chronic-Phase | - |
dc.subject | Cyclophosphamide | - |
dc.subject | Granulocyte Colony-Stimulating Factor | - |
dc.subject | Interferon-alpha | - |
dc.subject | Prognosis | - |
dc.subject | Treatment Outcome | - |
dc.subject | Leukapheresis | - |
dc.subject | Hematopoietic Stem Cell Transplantation | - |
dc.subject | Transplantation, Autologous | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Mobilization of predominantly Philadelphia chromosome-negative blood progenitors using cyclophosphamide and rHUG-CSF in early chronic-phase chronic myeloid leukaemia: correlation with Sokal prognostic index and haematological control. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1365-2141.1997.d01-2068.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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