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Type: Journal article
Title: Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm
Author: Tikhomirova, A.
Kidd, S.
Citation: Pathogens and Disease, 2013; 69(2):114-126
Publisher: Wiley
Issue Date: 2013
ISSN: 2049-632X
Statement of
Alexandra Tikhomirova and Stephen P. Kidd
Abstract: Streptococcus pneumoniae and Haemophilus influenzae are both commensals of the human nasopharynx with an ability to migrate to other niches within the human body to cause various diseases of the upper respiratory tract such as pneumonia, otitis media and bronchitis. They have long been detected together in a multispecies biofilm in infected tissue. However, an understanding of their interplay is a recent field of study, and while over recent years, there has been research that has identified many specific elements important in these biofilms, to date, it remains questionable whether the relationship between H. influenzae and S. pneumoniae is competitive or cooperative. Additionally, the factors that govern the nature of the interspecies interaction are still undefined. This review aims to collate the information that has emerged on the cocolonization and co-infection by S. pneumoniae and nontypeable H. influenzae (NTHi) and their formation of a multispecies biofilm.
Keywords: multispecies biofilms; nontypeable Haemophilus influenzae; otitis media; Streptococcus pneumoniae ; inter-species interactions; bacterial pathogenesis
Description: Article first published online: 10 SEP 2013
Rights: © 2013 Federation of European Microbiological Societies
RMID: 0030008748
DOI: 10.1111/2049-632X.12073
Appears in Collections:Molecular and Biomedical Science publications

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