Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87361
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Type: Journal article
Title: Improved detection of helix-turn-helix DNA-binding motifs in protein sequences
Author: Dodd, I.
Egan, J.
Citation: Nucleic Acids Research, 1990; 18(17):5019-5026
Publisher: Oxford University Press
Issue Date: 1990
ISSN: 0305-1048
1362-4962
Statement of
Responsibility: 
Ian B.Dodd and J.Barry Egan
Abstract: We present an update of our method for systematic detection and evaluation of potential hellx-turn-helix DNA-binding motifs in protein sequences [Dodd, I. and Egan, J. B. (1987) J. Mol. Biol. 194, 557-564]. The new method is considerably more powerful, detecting approximately 50% more likely hellx-turn-helix sequences without an Increase In false predictions. This improvement is due almost entirely to the use of a much larger reference set of 91 presumed helix-tumhellx sequences. The scoring matrix derived from this reference set has been calibrated against a large protein sequence database so that the score obtained by a sequence can be used to give a practical estimation of the probability that the sequence Is a helix-turn-helix motif.
Keywords: Animals; DNA-Binding Proteins; DNA; Probability; Amino Acid Sequence; Protein Conformation; Molecular Sequence Data; Information Systems
Rights: © 1990 Oxford University Press
RMID: 0030013128
DOI: 10.1093/nar/18.17.5019
Appears in Collections:Molecular and Biomedical Science publications

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