Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/87398
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Type: Journal article
Title: Changes in cystic fibrosis mortality in Australia, 1979-2005
Author: Reid, D.
Leigh Blizzard, C.
Shugg, D.
Flowers, C.
Cash, C.
Greville, H.
Citation: Medical Journal of Australia, 2011; 195(7):392-395
Publisher: MJA Group Australia
Issue Date: 2011
ISSN: 0025-729X
1326-5377
Statement of
Responsibility: 
David W Reid, C Leigh Blizzard, Dace M Shugg, Ceri Flowers, Catherine Cash, Hugh M Greville
Abstract: OBJECTIVE: To assess mortality trends among people with cystic fibrosis (CF) in Australia. DESIGN AND SETTING: We augmented Australian summary data for deaths from CF registered during 1979-2005 with information from Australian transplant centres on lung transplantation among CF patients for 1989-2005 to allow us to follow trends in all "mortality events" (death or lung transplantation). MAIN OUTCOME MEASURE: Age at death or lung transplantation. RESULTS: Between 1979 and 2005, the mean age at death increased from 12.2 years to 27.9 years for males and from 14.8 years to 25.3 years for females. Overall, female deaths in childhood (0-14 years) occurred at an age-standardised rate of 0.40 per 100,000 (95% CI, 0.34-0.45) during 1979-2005, which exceeded the corresponding rate for males of 0.24 (95% CI, 0.20-0.28) per 100,000. Among 0-14-year-old boys, event rates declined markedly after 1989, but they declined later and more gradually for girls, with the result that the age-standardised rate for girls was 2.38 times that of boys during 1989-2005 (95% CI, 1.69-3.36). CONCLUSIONS: The pattern of CF mortality in Australia has changed substantially. Mortality rates continue to be higher for girls than for boys, but death in childhood has become uncommon. Survival has increased since 1979, but females continue to have reduced length of life.
Keywords: Humans
Cystic Fibrosis
Prognosis
Lung Transplantation
Life Expectancy
Adolescent
Adult
Middle Aged
Child
Australia
Female
Male
Young Adult
Rights: Copyright status unknown
DOI: 10.5694/mja10.11229
Appears in Collections:Aurora harvest 7
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