Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87422
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dc.contributor.authorPlummer, M.en
dc.contributor.authorJones, K.en
dc.contributor.authorAnnink, C.en
dc.contributor.authorCousins, C.en
dc.contributor.authorMeier, J.en
dc.contributor.authorChapman, M.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorDeane, A.en
dc.date.issued2014en
dc.identifier.citationDiabetes Care, 2014; 37(6):1509-1515en
dc.identifier.issn0149-5992en
dc.identifier.issn1935-5548en
dc.identifier.urihttp://hdl.handle.net/2440/87422-
dc.description.abstractOBJECTIVE: Exogenous GLP-1 slows gastric emptying in health and diabetes leading to diminished glycemic excursions. Gastric emptying is markedly accelerated by hypoglycemia. The primary objective was to determine whether GLP-1 attenuates the acceleration of gastric emptying induced by hypoglycemia. RESEARCH DESIGN AND METHODS: Ten healthy volunteers were studied on four separate days in a randomized double-blind fashion. Blood glucose was stabilized using a glucose/insulin clamp at hypoglycemia (2.6 mmol/L on two occasions [hypo]) or euglycemia (6.0 mmol/L on two occasions [eu]) between T = -15 and 45 min before clamping at 6.0 mmol/L until 180 min. During hypoglycemia and euglycemia, subjects received intravenous GLP-1 (1.2 pmol/kg/min) or placebo. At T = 0 min, subjects ingested 100 g beef mince labeled with 20 MBq (99m)Tc-sulfur-colloid and 3 g of 3-O-methyl-glucose (3-OMG), a marker of glucose absorption. Gastric emptying was measured scintigraphically from T = 0 to 180 min and serum 3-OMG taken at 15-min intervals. The areas under the curve for gastric emptying and 3-OMG concentration were analyzed using one-way repeated-measures ANOVA with Bonferroni-Holm adjusted post hoc tests. RESULTS: Gastric emptying was accelerated during hypoglycemia (hypo/placebo vs. eu/placebo; P < 0.001), as was glucose absorption (P < 0.03). GLP-1 slowed emptying during euglycemia (eu/placebo vs. eu/GLP-1; P < 0.001). However, hypoglycemia-induced acceleration of gastric emptying on placebo was markedly diminished by GLP-1 (hypo/placebo vs. hypo/GLP-1; P < 0.008), as was glucose absorption (P < 0.01). CONCLUSIONS: Acute administration of exogenous GLP-1 attenuates, but does not abolish, the acceleration of gastric emptying by insulin-induced hypoglycemia in healthy subjects.en
dc.description.statementofresponsibilityMark P. Plummer, Karen L. Jones, Chris E. Annink, Caroline E. Cousins, Juris J. Meier, Marianne J. Chapman, Michael Horowitz and Adam M. Deaneen
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.rights© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.en
dc.subjectHumans; Hypoglycemia; Insulin; Blood Glucose; Hypoglycemic Agents; Glucose Clamp Technique; Injections, Intravenous; Double-Blind Method; Gastric Emptying; Aged; Middle Aged; Female; Male; Glucagon-Like Peptide 1; Incretins; Healthy Volunteersen
dc.titleGlucagon-like peptide 1 attenuates the acceleration of gastric emptying induced by hypoglycemia in healthy subjectsen
dc.typeJournal articleen
dc.identifier.rmid0030011080en
dc.identifier.doi10.2337/dc13-1813en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1025648en
dc.identifier.pubid107863-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS01en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidChapman, M. [0000-0003-0710-3283]en
dc.identifier.orcidDeane, A. [0000-0002-7620-5577]en
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